Erythropoietins and Erythropoiesis

This volume is a one-source guide to the most current information about
red blood cell formation and the action of recombinant human
erythropoietins. Topics in the fields of erythropoiesis, recombinant
protein discovery and production, and treatment of patients with anemia
will be covered. The newest theories in erythropoiesis (receptors,
signaling), manufacturing, new formulations, and clinical research are
discussed.
It is of interest to researchers and clinical investigators in academia
and biotechnology and pharmaceutical companies, to clinical research
associates, clinical monitors, and physician investigators. TOC:I. Background and basic science.- Erythropoiesis: an overview. Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin. Structural basis for the signal transduction of erythropoietin. Molecular biology of the erythropoietin receptor in hematopoietic and non-hematopoietic tissues. Erythropoietin receptor signaling processes. Clinical pharmacokinetic properties of rHuEPO: a review. Biology of erythropoietin. Commercial production of recombinant erythropoietins.- II. Clinical use of recombinant erythropoietins.- Use of recombinant erythropoietins in the setting of renal disease. Erythropoietic therapy in the practice of oncology. Use of recombinant erythropoietins for the treatment of anemia of chronic disease. Use of erythropoietins in the surgical setting. Abuse of recombinant erythropoietins by athletes. Antibodies to endogenous and recombinant erythropoietin. New molecules and formulations of recombinant human erythropoietin.- Glossary of terms and abbreviations.- Index.