Antigen Presentation

Antigen presentation is central to the immune response, and is instrumental in ensuring that the response mounted is that best suited to the eradication of the particular microbe faced. In this volume, experts in the field provide state-of-the-art descriptions of the antigen presentation pathways. How do viruses disrupt these critical pathways, and to what effect? Do all tissues present antigen in the same way? If not, why? What are the consequences of dysfunctional antigen presentation, seen in certain genetic disorders? This book considers not only the molecular details, but also their relevance to the whole organism. TOC:(Overview) - How Do Endogenous Proteins Become Peptides and Reach the Endoplasmic Reticulum.- Molecular Requirements for Assembly and Intracellular Transport of Class I Major HCM.- Peptide-Major HC Class I Complex.- Immune Response of ß2-Microglobulin-Deficient Mice to Pathogens.- CNS Neurons.- Suppression of MHC Class I Antigen Presentation by Human-Adenoviruses.- Herpesvirus Evastion of the Immune System.- Intracellular Transport of Molecules Engaged in the Presentation of Exogenous Antigen.