Advancing Methods for Biomolecular Crystallography

The Zen of Model Anomalies – Correct most of them. Treasure the meaningful valid few. Live serenely with the rest!; J. S. Richardson and D. C. Richardson.- Total Chemical Protein Synthesis for the Determination of Novel X-Ray Structures by Racemic Protein Crystallography; K. Mandal and S.B.H. Kent.- Crystal Pathologies; T. O. Yeates.- Crystallizing Membrane Proteins for Structure-Function Studies Using Lipidic Mesophases; M. Caffrey.- Searching for needles in haystacks: Automation and the task of Crystal Structure determination; S. McSweeney.- Data processing: how good are my data really?; K. Diederichs and P. A. Karplus.- Radiation Damage in Macromolecular Crystallography: what is it and why do we care?; E. F. Garman.- Elemental analysis of proteins by Proton Induced X-ray Emission (microPIXE); E. F. Garman, O. B. Zeldin.- X-rays-induced cooperative atomic movement in a protein crystal; T. Petrova et al.- Everything happens at once – Deconvolving systematic effects in X-ray data processing; D. Borek and Z. Otwinowski.- Extending the reach of molecular replacement; R.J. Read et al.- Phasing through location of small fragments and density modification with ARCIMBOLDO; I. Usón et al.- SAD/MAD phasing; Z. Dauter.- Macromolecular Phasing: Solving the Substructure; T. Gru¨ne.- Advanced Applications of Shelxd and Shelxe; T.Gru¨ne.-  Use of a weak anomalous signal for phasing in protein crystallography: Reflection from personal experience;  F. Frolow.- Ab initio low resolution phasing; V. Y. Lunin et al.- Model-building and Reduction of Model Bias in Electron Density Maps; T. C. Terwilliger.- Using Coot to Model Protein and Ligand Structures using X-ray data; P. Emsley.- Crystallographic Structure Refinement in a Nutshell; P. V. Afonine and P. D. Adams.- Crystallographic maps and models at low and at subatomic resolutions; A. Urzhumtsev et al.- Recent Advances in Low Resolution Refinement Tools in REFMAC; R. A. Nicholls et al.- High resolution macromolecular crystallography; M. Jaskolski.- Publishing in Proteopedia: The Guide; J. Prilusky et al.- Proteolysis, complex formation and conformational changes drive the complement pathways; P. Gros and F. Forneris.- Monoamine Oxidase Inhibitors: Diverse and Surprising Chemistry with expanding Pharmacological Potential; C. Binda et al.- Structure of the eukaryotic ribosome: tips and tricks; S. Melnikov.- Neutron Protein Crystallography. How to proceed the experiments to obtain the structural information of hydrogen, protons and hydration in Bio-macromolecules; N. Niimura.- Coherent diffraction and holographic imaging of individual biomolecules using low-energy electrons; T. Latychevskaia et al.-  Structure analysis of biological macromolecules by small-angle X-ray scattering; D. I.Svergun.- Protein structure modeling with Rosetta: Case studies in structure prediction and enzyme repurposing; F. DiMaio.