Rotaviruses

Provides a comprehensive review of the various aspects of rotavirus molecular biology and the biology of infection, host responses to infection and the prospects for vaccines to control rotavirus disease. Both group A and non-group A rotaviruses are examined.

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A comprehensive review is given of the various aspects of rotavirus molecular biology and the biology of infection, host responses to infection, and the prospects for vaccines to control rotavirus disease. The first few chapters review basic aspects of the group A rotaviruses, including the structure of the rotavirion, the structure of the rotavirus genome, and the structure and function of the viral proteins. Viral replication and genetics are discussed in separate chapters. A later section deals with the antigenic structure of the virus, the host response to infection, and the pathology and pathophysiology of infection. The information provided in these reviews is then applied to the problem of vaccine development in a subsequent chapter.