Lectins and Cancer
Springer Berlin (Hersteller)
978-3-540-54224-7 (ISBN)
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This work shows how the analysis of protein carbohydrate interactions can contribute to an understanding of tumour cell growth regulation and spread and can help with the establishment of rational methods for diagnosis and therapy.
Molecular recognition governs any aspect of cellular interaction. The analysis of protein carbohydrate interactions contributes to an understanding of tumour cell growth regulation and spread and can help with the establishment of rational methods for diagnosis and therapy. Techniques in oncology and pathology, such as the chemically and biochemically optimized preparation of adequate tools, their application for localization of receptor (tissue lectin) and ligand (cellular glycoconjugate) pairs in tumour cells and tumour sections and the usefulness of a lectin from a plant extract as a potent immunomodulator, are detailed.
Hans-Joachim Gabius obtained his Ph.D. in 1982 at the Max-Planck-Institute for Experimental Medicine in Göttingen. After doing post-doctoral research from 1984-1985 in the group of S. H. Barondes at the UC San Diego, he was appointed first as assistant professor for biochemistry at the Max-Planck-Institute for Experimental Medicine in Göttingen (1987) and then as associate professor for pharmaceutical chemistry atthe University of Marburg (1991). Since 1993 he is heading the Institute for Physiological Chemistry, Faculty of Veterinary Medicine at the University of Munich. Prof. Gabius received numerous research awards including the Otto-Hahn-Medal (1983), the Award of the Dr. Carl-Duisberg-Foundation (1988) and the Award of the Paul-Martini-Foundation (1990). His research interests are focused on chemical, biophysical and biochemical analysis of protein - carbohydrate interactions with biomedical relevance, such as the development of glycoscientific strategies for tumor diagnosis and therapy and the elucidation of functions of mammalian lectins. His research led to a prominent placement in the ISI ranking of highly cited papers in 1998.
| Illustrationen | Paul Günther |
|---|---|
| Zusatzinfo | 79 figs. |
| Sprache | englisch |
| Gewicht | 676 g |
| Einbandart | gebunden |
| Schlagworte | Krebs (Krankheit) • Krebs (Krankheit) / Karzinom • Lektin |
| ISBN-10 | 3-540-54224-8 / 3540542248 |
| ISBN-13 | 978-3-540-54224-7 / 9783540542247 |
| Zustand | Neuware |
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