Current Topics in Clinical Radiobiology of Tumors

Examining controversial areas in the field of clinical radiobiology, this study presents a critical appraisal of clinical results obtained from the application of hyperfractionation and accelerated fractionation.

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This provides an update of topics that at present constitute the main controversies in the field of clinical radiobiology. A critical appraisal is given of the clinical results obtained so far by the application of hyperfractionation and accelerated fractionation. In addition, the possibilities and limitations of the methods for evaluation of nonrandomized clinical studies to derive time-dose relationships for human tumours, the use of the BUDR technique for determination of tumour proliferation characteristics, the validity of the linear-quadratic model at low doses per fraction, the predictive value of SF2 for the outcome of radiotherapy, and methods for the identification of hypoxic cells are critically reviewed.