Metallothioneins and Related Chelators

Astrid Sigel has studied languages and was an editor of the Metal Ions in Biological Systems series (until Volume 44) and also of the Handbooks on Toxicity of Inorganic Compounds (1988), on Metals in Clinical and Analytical Chemistry (1994; both with H. G. Seiler) and on Metalloproteins (2001; with Ivano Bertini). Helmut Sigel is Emeritus Professor (2003) of Inorganic Chemistry at the University of Basel, Switzerland, and a previous editor of the MIBS series until Volume 44. He serves on various editorial and advisory boards, published over 300 articles on metal ion complexes of nucleotides, coenzymes, and other ligands of biological relevance, and lectured worldwide. He was named Protagonist in Chemistry (2002) by ICA (issue 339); among further honors are the P. Ray Award (Indian Chemical Society, of which he is also an Honorary Fellow), the Werner Award (Swiss Chemical Society), a Doctor of Science honoris causa degree (Kalyani University, India), appointments as Visiting Professor (e.g., Austria, China, Japan, UK) and Endowed Lectureships. Roland K. O. Sigel is Associate Professor (2009) of Inorganic Chemistry at the University of Z³rich, Switzerland,; from 2003 to 2008 he was endowed with a F÷rderungsprofessur of the Swiss National Science Foundation. He received his doctoral degree summa cum laude (1999) from the University of Dortmund, Germany, working with Bernhard Lippert. Thereafter he spent nearly three years at Columbia University, New York, USA, with Anna Marie Pyle (now Yale University). During the six years abroad he received several prestigeous fellowships from various sources, and he was awarded the EuroBIC Medal in 2008. His research focuses on the structural and catalytic role of metal ions in ribozymes, especially group II introns, and on related topics. He was also an editor of Volumes 43 and 44 of the MIBS series.

Chapter 1: METALLOTHIONEINS. HISTORICAL DEVELOPMENT AND OVERVIEW;

Chapter 2: REGULATION OF METALLOTHIONEIN GENE EXPRESSION;

Chapter 3: BACTERIAL METALLOTHIONEINS;

Chapter 4: METALLOTHIONEINS IN YEAST AND FUNGI;

Chapter 5: METALLOTHIONEINS IN PLANTS;

Chapter 6: METALLOTHIONEINS IN DIPTERA;

Chapter 7: EARTHWORM AND NEMATODE METALLOTHIONEINS;

Chapter 8: METALLOTHIONEINS IN AQUATIC ORGANISMS: FISH, CRUSTACEANS, MOLLUSCS, AND ECHINODERMS;

Chapter 9: METAL DETOXIFICATION IN FRESHWATER ANIMALS. ROLES OF METALLOTHIONEINS;

Chapter 10: STRUCTURE AND FUNCTION OF VERTEBRATE METALLOTHIONEINS;

Chapter 11: METALLOTHIONEIN-3, ZINC, AND COPPER IN THE CENTRAL NERVOUS SYSTEM;

Chapter 12: METALLOTHIONEIN TOXICOLOGY: METAL ION TRAFFICKING AND CELLULAR PROTECTION;

Chapter 13: METALLTHIONEIN IN INORGANIC CARCINOGENESIS;

Chapter 14: THIOREDOXINS AND GLUTAREDOXINS. FUNCTIONS AND METAL ION INTERACTIONS;

Chapter 15: METAL ION-BINDING PROPERTIES OF PHYTOCHELATINS AND RELATED LIGANDS