Tropomyosin

PETER GUNNING, PhD, is Head of the Oncology Research Unit, Department of Pharmacology, School of Medical Sciences, at the University of New South Wales located in Sydney, Australia. The primary focus of his research is the regulation of cell and tissue architecture and its modification in cancer. He is a member of numerous professional organisations and has served on the Boards of the NSW Cancer Council and Bio-Link Partners and as Chairman of the NSW Cancer Council and NSW Cancer Institute Research Committees. Peter received his academic degrees from Monash University, Melbourne, Australia.

and Historical Perspective.- and Historical Perspective.- Genes and Their Expression.- Structure and Evolution of Tropomyosin Genes.- Tropomyosin Exons as Models for Alternative Splicing.- Tropomyosin Gene Expression in Vivo and in Vitro.- Protein Structure.- Tropomyosin: Function Follows Structure.- Dimerization of Tropomyosins.- Role in Muscle Function.- Cooperative Binding of Tropomyosin to Actin.- Tropomyosin and the Steric Mechanism of Muscle Regulation.- Role of Tropomyosin in the Regulation of Contraction in Smooth Muscle.- Tropomyosin in Human Disease.- Tropomyosin as a Regulator of Cancer Cell Transformation.- The Role of Tropomyosin in Heart Disease.- Tropomyosins in Skeletal Muscle Diseases.- Tropomyosins in Human Diseases: Ulcerative Colitis.- Tropomyosin Directed Regulation of the Cytoskeleton.- Tropomyosin Function in Yeast.- Isoform Sorting of Tropomyosins.- Human Tropomyosin Isoforms in the Regulation of Cytoskeleton Functions.- Mechanisms of Tropomyosin Function.- Tropomyosins Regulate the Impact of Actin Binding Proteins on Actin Filaments.- Tropomyosin and ADF/Cofilin as Collaborators and Competitors.- Caldesmon and the Regulation of Cytoskeletal Functions.- Tropomyosins as Discriminators of Myosin Function.- Tropomodulin/Tropomyosin Interactions Regulate Actin Pointed End Dynamics.- Conclusion.- Emerging Issues for Tropomyosin Structure, Regulation, Function and Pathology.