Using Mass Spectrometry for Drug Metabolism Studies -

Using Mass Spectrometry for Drug Metabolism Studies

Walter A. Korfmacher (Herausgeber)

Buch | Hardcover
452 Seiten
2009 | 2nd edition
Crc Press Inc (Verlag)
978-1-4200-9220-2 (ISBN)
259,95 inkl. MwSt
Offers information on various findings regarding biomarkers and metabolomics. This book presents an overview of the entire drug discovery process, including various developments in molecular research.
The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicinal chemists and mass spectrometry professionals up to speed with the rapid advances in the field, the emergence of cutting-edge approaches, and ways to meet steadily increasing vendor demands. Written by international scientists who are experts in their respective disciplines, this state-of-the-art reference effectively encapsulates current mass spectrometry best practices.



The stand-alone chapters cover various topics – from metabolite identification to fast chromatography with UPLC – and in a style that is understandable to experts and field newcomers alike. The second edition of this bestseller includes coverage of new instrumentation and software as well as a wealth of updated information on the latest findings surrounding biomarkers and metabolomics and new chapters on both UPLC and DESI/DART.



With more than 180 illustrations and an eight-page color insert, this valuable reference explores multiple modern mass spectrometry techniques and strategies. It includes an excellent overview of the entire drug discovery process plus the latest developments on how mass spectrometry is used to support this endeavor.

Walter A. Korfmacher

Strategies and Techniques for Bioanalytical Assays as Part of New Drug Discovery. The Drug Discovery Process: From Molecules to Drugs. PK Principles and PK/PD Applications. Mass Spectrometry for In Vitro ADME Screening. Metabolite Identification Strategies and Procedures. Reactive Metabolite Screening and Covalent-Binding Assays. Fast Metabolite Screening in a Discovery Setting. Fast Chromatography with UPLC and Other Techniques. Supercritical Fluid Chromatography–Mass Spectrometry. Biomarkers of Efficacy and Toxicity: Discovery and Assay. Imaging Mass Spectrometry for Small Molecules. MALDI IMS for Proteins and Biomarkers. Ambient Ionization Methods and Their Early Applications in ADME Studies. Pharmaceutical Applications of Accelerator Mass Spectrometry.

Erscheint lt. Verlag 9.11.2009
Verlagsort Bosa Roca
Sprache englisch
Maße 156 x 234 mm
Gewicht 758 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Naturwissenschaften Biologie
Naturwissenschaften Chemie Analytische Chemie
Technik
ISBN-10 1-4200-9220-0 / 1420092200
ISBN-13 978-1-4200-9220-2 / 9781420092202
Zustand Neuware
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