The Sugar Code

Fundamentals of Glycosciences

Hans-Joachim Gabius (Herausgeber)

Buch | Hardcover
XXVIII, 569 Seiten
2009 | 1. Auflage
Wiley-VCH (Verlag)
978-3-527-32089-9 (ISBN)

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The Sugar Code -
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A comprehensive introduction into glycobiology, an expanding field with increasing biomedical relevance, e.g. for infectious diseases or cancer.
One of the few books to comprehensively cover the biochemistry of biologically relevant glycomolecules as well as the relevance in health and disease.
Ein neues Lehrbuch der Glykobiologie, das einen umfassenden Einblick in die Biochemie und die biologische und medizinische Relevanz von glykosylierten Biomolekülen gibt. Zusammengestellt von einem führenden Pionier auf dem Gebiet gemeinsam mit einem internationalen Expertenteam.

Hans-Joachim Gabius obtained his Ph.D. in 1982 at the Max-Planck-Institute for Experimental Medicine in Göttingen. After doing post-doctoral research from 1984-1985 in the group of S. H. Barondes at the UC San Diego, he was appointed first as assistant professor for biochemistry at the Max-Planck-Institute for Experimental Medicine in Göttingen (1987) and then as associate professor for pharmaceutical chemistry at the University of Marburg (1991). Since 1993 he is heading the Institute for Physiological Chemistry, Faculty of Veterinary Medicine at the University of Munich. Prof. Gabius received numerous research awards including the Otto-Hahn-Medal (1983), the Award of the Dr. Carl-Duisberg-Foundation (1988) and the Award of the Paul-Martini-Foundation (1990). His research interests are focused on chemical, biophysical and biochemical analysis of protein - carbohydrate interactions with biomedical relevance, such as the development of glycoscientific strategies for tumor diagnosis and therapy and the elucidation of functions of mammalian lectins. His research led to a prominent placement in the ISI ranking of highly cited papers in 1998.

CHEMICAL BASIS
The Biochemical Basis and Coding Capacity of the Sugar Code (Rüdiger, Gabius)
Three-dimensional Aspects of the Sugar Code (Kozár, André, Ulicny, Gabius)
The Chemist's Way to Synthesize Glycosides (Oscarson)
The Chemist's Way to Prepare Multivalency (Chabre, Roy)
Analytical Aspects: The Analysis of Protein-Bound Glycans (Nakagawa)
NATURAL GLYCOSYLATION - GLYCOPROTEINS
N-Glycosylation (Zuber, Roth)
O-Glycosylation: Structural Diversity and Functions (Patsos, Corfield)
Glycosylation of Model and "Lower" Organisms (Wilson, Paschinger, Rendic)
Glycosylphosphatidylinositol Anchors: Structure, Biosynthesis and Functions (Shams-Eldin, Debierre-Grockiego, Schwarz)
NATURAL GLYCOSYLATION - GLYCOLIPIDS, PROTEOGLYCANS, CHITIN
Glycolipids (Kopitz)
Proteoglycans (Buddecke)
Chitin (Merzendorfer)
PROTEIN-CARBOHYDRATE INTERACTIONS
Protein-Carbohydrate Interactions: Basic Concepts and Methods for Analysis (Solís, Romero, Menéndez, Jiménez-Barbero)
How to Determine Specificity: From Lectin Profiling to Glycan Mapping and Arrays (Tateno, Kuno, Hirabayashi)
The History of Lectinology (Rüdiger, Gabius)
Ca2+: Mastermind and Active Player for Lectin Activity (Including a Gallery of Lectin Folds) (Gabius)
Bacterial and Viral Lectins (Holgersson, Gustafsson, Gaunitz)
Plant Lectins (Rüdiger, Gabius)
Animal and Human Lectins (Gabius)
Routes in Lectin Evolution: Case Study on the C-Type Lectin-Like Domains (Gready, Zelensky)
Carbohydrate-Carbohydrate Interactions (Bucior, Burger, Fernàndez-Busquets)
BIOMEDICAL ASPECTS AND CASE STUDIES
Diseases of Glycosylation (Hennet)
Animal Models to Delineate Glycan Functionality (Honke, Taniguchi)
Glycobiology of Fertilization and Early Embryonic Development (Habermann, Sinowatz)
Glycans as Functional Markers in Malignancy? (André, Kopitz, Kaltner, Villalobo, Gabius)
Small is Beautiful: Mini-Lectins in Host Defense (Lehrer)
Inflammation and Glycosciences (Schwartz-Albiez)
Sugars as Pharmaceuticals (Osborn, Turkson)
Platelet Glycoproteins as Lectins in Hematology (Hoffmeister, Falet)
Neurobiology meets Glycosciences (Ledeen, Wu)

COMPANION WEB-SITE: www.wiley-vch.de/home/thesugarcode

"In summary, this ambitious book is a must-have for every library collection on carbohydrates and a great resource for chemistry and biology students curious for an entry into the rapidly growing area of glycosciences. The decoding process has just begun." ( ChemBioChem , 2010)

Erscheint lt. Verlag 23.9.2009
Sprache englisch
Maße 170 x 240 mm
Gewicht 1260 g
Themenwelt Naturwissenschaften Biologie Mikrobiologie / Immunologie
Schlagworte Biochemie • Biochemie u. Chemische Biologie • Biochemistry (Chemical Biology) • Biologie • Biowissenschaften • Cell & Molecular Biology • Cell & Molecular Biology • Chemie • Chemistry • Glykobiologie • Glykoprotein • Glyko-Verbindungen • Life Sciences • Molekularbiologie • Zellbiologie • Zell- u. Molekularbiologie
ISBN-10 3-527-32089-X / 352732089X
ISBN-13 978-3-527-32089-9 / 9783527320899
Zustand Neuware
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