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Oncogenes Meet Metabolism

From Deregulated Genes to a Broader Understanding of Tumour Physiology

Guido Kroemer, Dominik Mumberg, Kector Keun, Björn Riefke, Thomas Steger-Hartmann, Kirstin Petersen (Herausgeber)

Buch | Hardcover

XV, 265 Seiten

2008 | 2008
Springer Berlin (Verlag)
978-3-540-79477-6 (ISBN)

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In 1920s, Otto Warburg described the phenomenon of 'aerobic glycolysis', the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg's hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).

Mitochondria and Cancer.- Role of the Metabolic Stress Responses of Apoptosis and Autophagy in Tumor Suppression.- The Interplay Between MYC and HIF in the Warburg Effect.- Using Metabolomics to Monitor Anticancer Drugs.- Biomarker Discovery for Drug Development and Translational Medicine Using Metabonomics.- Pyruvate Kinase Type M2: A Key Regulator Within the Tumour Metabolome and a Tool for Metabolic Profiling of Tumours.- Molecular Imaging of Tumor Metabolism and Apoptosis.- Minimally Invasive Biomarkers for Therapy Monitoring.- Use of Metabolic Pathway Flux Information in Anticancer Drug Design.- Cancer Diagnostics Using 1H-NMR-Based Metabonomics.- Human Metabolic Phenotyping and Metabolome Wide Association Studies.- Defining Personal Nutrition and Metabolic Health Through Metabonomics.

Erscheint lt. Verlag	20.8.2008
Reihe/Serie	Ernst Schering Foundation Symposium Proceedings
Zusatzinfo	XV, 265 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	590 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Naturwissenschaften ► Chemie ► Analytische Chemie
Schlagworte	Biomarkers • Cancer Research • Cells • Diagnostics • metabolic profiling • Metabonomics • Physiology • tissue • Warburg Effect
ISBN-10	3-540-79477-8 / 3540794778
ISBN-13	978-3-540-79477-6 / 9783540794776
Zustand	Neuware