Recent Advances in Thrombosis and Hemostasis

Coagulation Mechanism.- Structure and Functions of Fibrinogen and Fibrin.- Vitamin K Cycles and ?-Carboxylation of Coagulation Factors.- Synthesis and Secretion of Coagulation Factor VIII.- Structure and Biological Function of Factor XI.- Structural Insights into the Life History of Thrombin.- A Molecular Model of the Human Prothrombinase Complex.- Lipid Mediators and Tissue Factor Expression.- Tissue Factor Pathway Inhibitor: Structure and Function.- Biology of an Antithrombotic Factor—ADAMTS13.- Antithrombin and Heparin Cofactor II: Structure and Functions.- Endothelial Cells and Inflammation.- High-Mobility Group Box 1: Missing Link Between Thrombosis and Inflammation?.- Coagulation, Inflammation, and Tissue Remodeling.- Structure and Function of the Endothelial Cell Protein C Receptor.- New Aspects of Antiinflammatory Activity of Antithrombin: Molecular Mechanism(s) and Therapeutic Implications.- Platelets.- Platelet Collagen Receptors.- Positive and Negative Regulation of Integrin Function.- GPIb-Related Signaling Pathways in Platelets.- Sphingosine 1-Phosphate as a Platelet-Derived Bioactive Lipid.- Polymorphisms of Platelet Membrane Glycoproteins.- Platelet Procoagulant Activity Appeared by Exposure of Platelets to Blood Flow Conditions.- Tissue Proteolysis.- Regulation of Cellular uPA Activity and Its Implication in Pathogenesis of Diseases.- Role of tPA in the Neural System.- Role of Fibrinolysis in the Nasal System.- Role of Fibrinolysis in Hepatic Regeneration.- Pathophysiology of Transglutaminases Including Factor FXIII.- Vascular Development and Regeneration.- A Linkage in the Developmental Pathway of Vascular and Hematopoietic Cells.- Atherosclerosis and Angiogenesis: Double Face of Neovascularization in Atherosclerotic Intima and Collateral Vessels inIschemic Organs.- Hemorrhagic Diathesis.- Hemophilia A and Inhibitors.- von Willebrand Disease: Diagnosis and Treatment.- Other Topics of Thrombosis and Hemostasis.- Age-Related Homeostasis and Hemostatic System.- Molecular Evolution of Blood Clotting Factors with Special Reference to Fibrinogen and von Willebrand Factor.- Snake Venoms and Other Toxic Components Affecting Thrombosis and Hemostasis.- Structures and Potential Roles of Oligosaccharides in Human Coagulation Factors and von Willebrand Factor.- Clinicals: Thrombosis-related Disorders and Recent Topics.- Hypercoagulable States.- Etiopathology of the Antiphospholipid Syndrome.- Malignancy and Thrombosis.- Disseminated Intravascular Coagulation.- Current Clinical Status of Venous Thromboembolism in Japan.- Platelet Activity and Antiplatelet Therapy in Patients with Ischemic Stroke and Transient Ischemic Attack.- Clinical Role of Recombinant Factor Vlla in Bleeding Disorders.- Clinical Role of Protein S Deficiency in Asian Population.- Atherothrombosis and Thrombus Propagation.- Thrombotic Microangiopathy.

Aus den Rezensionen:

“Das Werk ... ist gekennzeichnet von großer fachlicher Kompetenz und wissenschaftlicher Erfahrung der Autoren und Herausgeber. Die Hämostaseologie wird aufgrund neuester Erfahrungen modern und spannend dargestellt. ... Die fachliche Kompetenz der Autoren durchzieht sämtliche Texte dieses herausragenden Werkes über Thrombose und Hämostase. Wegen seiner Aktualität sollte es in keiner Bibliothek eines interessierten Hämostaseologen fehlen. Wir wünschen dem Werk eine weite Verbreitung in allen Fachkreisen der Hämostaseologie.“ (H. D. Bruhn, in: Hämastaseologie, January/2010, Issue 1, S. 42)