The Design of Synthetic Inhibitors of Thrombin

The Rational Design of Thrombin-Directed Antithrombotics.- X-Ray Crystal Structures of Thrombin in Complex with D-Phe-Pro-Arg and with Small Benzamidine and Arginine-Based “Non-Peptidic” Inhibitors.- Inhibitor Binding to Thrombin: X-Ray Crystallographic Studies.- Molecular Basis for the Inhibition of Thrombin by Hirudin.- Biophysical Studies of Interactions of Hirudin Analogs with Bovine and Human Thrombin by ESR and Fluorescence Labelling Studies.- pH-Dependent Binding Constants for the Inhibition of Thrombin by Transition State Analogues.- The Comparison of an Interim Tertiary Predicted Model of Bovine Thrombin and the X-Ray Structure of Human Thrombin.- Design of Novel Types of Thrombin Inhibitors Based on Modified D-Phe-Pro-Arg sequences.- Chemistry and Biology of the Peptide Anticoagulant D-MePhe-Pro-Arg-H (GYKI-14766).- Peptide Boronic Acid Inhibitors of Thrombin.- In Vitro and In Vivo Properties of Synthetic Inhibitors of Thrombin: Recent Advances.- The Use of Isosteric Bonds in the Design of Thrombin Inhibitors.- Synthetic Thrombin Inhibitors as Anticoagulants Pharmacological Aspects.- New Peptide Boronic Acid Inhibitors of Thrombin.- Substrate-Related Phosphonopeptides as Thrombin Inhibitors.- The Synthesis and Anticoagulant Activity of Novel Peptidylfluoroalkanes.- Transition State Analogue Inhibitors of Thrombin: Synthesis Activity and Molecular Modelling.- Hirudin: The Famous Anticoagulant Agent.- Mechanisms for the Anticoagulant Effects of Synthetic Antithrombins.- Pre-Clinical and Clinical Studies on Hirulog: A Potent and Specific Direct Thrombin Inhibitor.- The Effect of Recombinant Hirudin on Arterial Thrombosis.