ANCA-Associated Vasculitides -

ANCA-Associated Vasculitides

Immunological and Clinical Aspects

Wolfgang L. Gross (Herausgeber)

Buch | Hardcover
552 Seiten
1993
Kluwer Academic/Plenum Publishers (Verlag)
978-0-306-44573-6 (ISBN)
341,33 inkl. MwSt
Proceedings of the Fourth International Workshop on ANCA and the Second International Colloquium on Wegener's Granulomatosis and Vasculitic Disorders held in Lubeck, Germany, May 28-30, 1992
WEGENER'S GRANULOMATOSIS & ANCA-ASSOCIATED DISEASES: THE STORY CONTINUES The disease now designated as Wegener's granulomatosis (WG) was first described in 1931 by Heinz Klinger, who considered it to be a special form of polyarteritis nodosa. Klinger's friend, Friedrich Wegener, expanded on the first observations and interpreted the pathological and clinical fmdings to represent a distinct disease entity (Wegener, 1939). He described this entity as a "peculiar rhinogenous granulomatosis with a unique participation of the arterial system and the kidneys". Later, Godman and Churg (1954) established the classical diagnostic criteria (the "WG triad"): granuloma, vasculitis, and glomerulonephritis. In 1958 Walton pointed out the poor prognosis of WG based on a small number of published cases (mean survival time: 5 months). In 1966 Carrington and Liebow reported "limited forms" of WG with a defmitely more favorable prognosis. Since then positive results have been reported with cyclophosphamide therapy. In addition, a retrospective study of combined low-dose cyclophosphamide and prednisolone in 85 WG patients over a period of 21 years found a similarly encouraging outcome.
The*latter experience led to the current "standard" treatment protocol (FAUCI et al. , 1973 and 1983). More recently, strong evidence has emerged that some of the morbidity and mortality ofWG - and other types of systemic vasculitis - may be a consequence of this treatment (Hoffman et al. , 1992).

Friedrich Wegener and the Nature of Fame.- Pathophysiological Aspects and Antigen Specificity.- Clinical Aspects of Wegener’s Granulomatosis and other ANCA-Associated Diseases.

Erscheint lt. Verlag 30.11.1993
Reihe/Serie Advances in Experimental Medicine and Biology ; 336
Zusatzinfo XX, 552 p.
Verlagsort New York
Sprache englisch
Maße 156 x 234 mm
Themenwelt Medizinische Fachgebiete Innere Medizin Hämatologie
Naturwissenschaften Biologie Zoologie
ISBN-10 0-306-44573-5 / 0306445735
ISBN-13 978-0-306-44573-6 / 9780306445736
Zustand Neuware
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