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Novartis Foundation Symposium 291 – The Biology of Extracellular Molecular Chaperones
Wiley-Blackwell (Hersteller)
978-0-470-75403-0 (ISBN)
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More recently evidence has accumulated to show that certain molecular chaperones are also present on the surface of cells or in extracellular fluids. A new paradigm is emerging: at least some molecular chaperones are secreted proteins with pro- or anti-inflammatory actions, regulating the immune response in human diseases such as coronary heart disease, diabetes and rheumatoid arthritis. In addition to having direct effects on cells, molecular chaperones can bind peptides and present them to T cells to modulate immune responses. This may be significant in the treatment of cancer. This is the first book bringing leading researchers in this field together to review and discuss:* our current knowledge of cell stress response and molecular chaperones* the changing paradigms of protein trafficking and function* cell stress proteins as immunomodulators and pro- and anti-inflammatory signalling molecules* the role of these proteins in various chronic diseases and their potential as preventative or therapeutic agents.
The Biology of Extracellular Molecular Chaperones is of particular interest to immunologists, cell and molecular biologists, microbiologists and virologists, as well as clinical researchers working in cardiology, diabetes, rheumatoid arthritis and other inflammatory diseases.
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research. Chair: Peter Csermely.
Symposium on The biology of extracellular molecular chaperones, held at the Novartis Foundation, London, 5-7 June 2007. Editors: Derek J. Chadwick (Organizer) and Jamie Goode. This symposium is based on a proposal made by Brian Henderson, R. John Ellis and A. Graham Pockley Peter Csermely Chair's introduction. Jodie Haak and Kevin C. Kregel 1962-2007: a cell stress odyssey. Discussion. Peter A. Lund and R. John Ellis The chaperone function: meanings and myths. Discussion. Peter Csermely, Tamas Korcsmaros, Istvan A. Kovacs, Mate S. Szalay and Csaba Soti Systems biology of molecular chaperone networks. Discussion. Radhey S. Gupta , Nallur B. Ramachandra, Timothy Bowes and Bhag Singh Unusual cellular disposition of the mitochondrial molecular chaperones Hsp60, Hsp70 and Hsp10. Discussion. Martha Triantafilou, Daniel Sawyer, Abdiaziz Nor, Emmanouil Vakakis and Kathy Triantafilou Cell surface molecular chaperones as endogenous modulators of the innate immune response. Discussion. A. Graham Pockley and Gabriele Multhoff Cell stress proteins in extracellular fluids: friend or foe? Discussion. Francisco J. Quintana and Irun R. Cohen HSP60 speaks to the immune system in many voices. Discussion. Stuart K. Calderwood, Jianlin Gong, Jimmy R. Theriault, Salamatu S. Mambula and Philip J. Gray Jnr Cell stress proteins: novel immunotherapeutics. Discussion. General discussion. Brian Henderson Cell stress proteins as modulators of bacteria-host interactions. Discussion. Anthony R. M. Coates, Ana Cehovin and Yanmin Hu Chaperonin 60 and macrophage activation. Discussion. Alexzander Asea Hsp70: a chaperokine. Discussion. Hajime Nakamura Extracellular functions of thioredoxin. Discussion. Carol L. Miller-Graziano, Asit De, Krzysztof Laudanski, Tara Herrmann and Sanjukta Bandyopadhyay HSP27: an anti-inflammatory and immunomodulatory stress protein acting to dampen immune function. Discussion. Gabriel S. Panayi and Valerie M. Corrigall BiP, an anti-inflammatory ER protein, is a potential new therapy for the treatment of rheumatoid arthritis. Discussion. Final discussion. Index of contributors. Subject index.
Erscheint lt. Verlag | 1.6.2008 |
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Verlagsort | Hoboken |
Sprache | englisch |
Maße | 164 x 238 mm |
Gewicht | 530 g |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete |
Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie | |
Naturwissenschaften ► Biologie ► Biochemie | |
ISBN-10 | 0-470-75403-6 / 0470754036 |
ISBN-13 | 978-0-470-75403-0 / 9780470754030 |
Zustand | Neuware |
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