Organic Synthesis with Enzymes in Non-Aqueous Media

Dr. Giacomo Carrea joined the Italian National Research Council (CNR) in 1969 where presently he is Director of the Institute of Chemistry of Molecular Recognition. He has been working in such fields as enzyme catalysis in organic solvents, synthesis of fine chemicals catalyzed by hydrolases, dehydrogenases, peroxidases and monooxygenases, study of conformation of proteins and polypeptides and analytical applications of bioluminescent enzymes. He is a member of the Editorial Board of "Trends in Biotechnology" and "Biocatalysis and Biotransformation" and the author of about 220 publications in international peer reviewed journals. Dr. Sergio Riva is a Senior Research Scientist at the Institute of the Chemistry of Molecular Recognition. He took his Laurea in Chemistry in 1983 and his Diploma di Specialita? in Organic Synthesis in 1989. In 1987 he was at M.I.T. (USA) working with Prof. A. Klibanov. In 1993 he was awarded the Ciamician medal by the Organic Chemical Division of the Italian Chemical Society for his research activity in biocatalysis, presently documented by more than 150 publications reporting on the isolation and characterization of enzymes and on the synthetic exploitation of these biocatalysts.

Introduction (G. Carrea and S. Riva)
PART I: BIOCATALYSIS IN NEAT ORGANIC SOLVENTS - FUNDAMENTALS
Fundamentals of biocatalysis in neat organic solvents (Patrick Adlercreutz)
Effects of organic solvents on enzyme selectivity (Jaap Jongejan)
Activating enzymes for use in organic solvents (Anne Serdakowski and Jonathan Dordick)
PART II: BIOCATALYSIS IN NEAT ORGANIC SOLVENTS - SYNTHETIC APPLICATIONS
Exploiting enantioselectivity of hydrolases in organic solvents (Hans-Erik Hogberg)
Enzymatic dynamic kinetic resolution processes (Jan Backvall)
Exploiting enzyme regioselectivity and chemoselectivity (Sergio Riva)
Industrial scale applications of enzymes in non aqueous solvents (David Pollard and Birgit Kosjek)
PART III: BIOCATALYSIS IN BIPHASIC AND NEW REACTION MEDIA
Biocatalysis in biphasic systems: general (Pedro Fernandes and Joaquim Cabral)
Biocatalysis in biphasic systems: oxynitrilases (Manuela Avi and Herfried Griengl
Ionic liquids as media for enzymatic transformations (Roger Sheldon and Fred van Rantwijk)
Solid/gas biocatalysis (Isabelle Goubet, Marianne Graber, Sylvain Lamare, Thierry Maugard and Marie-Dominique Legoy)
Biocatalysis with undissolved solid substrates and products (Alessandra Basso, Sara Cantone, Cynthia Ebert, Peter Halling and Lucia Gardossi)

" Organic Synthesis with Enzymes in Non-Aqueous Media provides an excellent overview of the fundamental principles and utility of biocatalysts in organic transformations and represents a comprehensive reference guide for both organic chemists and enzymologists interested in the field." ( Journal of the American Chemical Society , November 12, 2008)
"The combination of basic background theory with a good number of examples attracts the reader. Therefore, I can highly recommend this book to chemists from industry and academia who are working in this field as well as to students. Chemists who are not yet working in this field may be inspired and encouraged to consider also biocatalysts to solve their synthetic problems." ( ChemSusChem 2008, 1, 467)