Cellular and Molecular Biology of Nitric Oxide

Jeffrey D. Laskin, Debra L. Laskin

Transcriptional regulation of the genes encoding nitric oxide synthase; arginine synthesis, metabolism, and transport - regulators of nitric oxide synthesis; inactivation of nitric oxide synthase isoforms by metalloporphyrins; nitric oxide, peroxynitrite, and carbon monoxide poisoning; structure-activity relationships in NOS inhibitors; homeostatic and pathological actions of nitric oxide in the kidney; roles of protein kinase C in the synthesis and cellular action of nitric oxide; nitric oxide and inflammation in autoimmune disorders; protective and pathologic roles of nitric oxide in tissue injury; nitric oxide and cell death in inflammation; nitric oxide as a cellular mediator of apoptosis; nitric oxide biosynthesis and metabolism in keratinocytes - the functions and consequences of nitric oxide production in the skin; taurine chloramine, an inhibitor of iNOS expression and a potential modulator of inflammation; modulation of the nitric oxide pathway by natural products; the role of DNA synthesis and cytokine-generated oxidants in hepatocyte necrosis and apoptosis.