Quantitative MRI of the Brain – Measuring Changes Caused by Disease

Professor Paul Tofts has worked on the physical aspects of quantitative brain imaging since the early days of clinical NMR. He was the first to measure in-vivo concentrations of metabolites, and to use dynamic imaging to measure blood-brain barrier permeability and extra-cellular space in multiple sclerosis.

Contributors. Reviewers. Foreward. Introduction. SECTION A: THE MEASUREMENT PROCESS. 1. Concepts: Measurement and MR (Paul S. Tofts). 2. The Measurement Process: MR Data Collection and Image Analysis (Paul S. Tofts). 3. QA: Quality Assurance, Accuracy, Precision and Phantoms (Paul S. Tofts). SECTION B: WINDOWS INTO THE BRAIN; MEASURING MR PARAMETERS. 4. PD: Proton Density of Tissue Water (Paul Tofts). 5. T1: the Longitudinal Relaxation Time (Penny A. Gowland and Valerie L. Stevenson). 6. T2: the Transverse Relaxation Time (Philip A. Boulby and Fergus J. Rugg-Gunn). 7. D: the Diffusion of Water (Claudia A.M. Wheeler-Kingshott, Gareth J. Barker, Stefan C.A. Steens and Mark A. van Buchem). 8. MT: Magnetisation Transfer (Paul S. Tofts, Stefan C.A. Steens and Mark A. van Buchem). 9. Spectroscopy: 1H Metabolite Concentrations (Paul S. Tofts and Adam D. Waldman). 10. T1-w DCE-MRI: T1-weighted Dynamic Contrast-enhance d MRI (Geoff J.M. Parker and Anwar Padhani). 11. T2- and T2-w DCE-MRI: Blood Perfusion and Volume Estimation using Bolus Tracking (Richard P. Kennan and H. Rolf Ja..ger). 12. Functional MRI (Peter Jezzard and Nick F. Ramsay). 13. ASL: Blood Perfusion Measurements using Arterial Spin Labelling (Laura M. Parkes, John A. Detre). SECTION C: THE BIOLOGY. 14. Biology: The Significance of MR Parameters in Multiple Sclerosis (Bruno Brochet, Klaus G. Petry and Vincent Dousset). SECTION D: ANALYSING IMAGES. 15. Spatial Registration of Images (John Ashburner and Catriona D. Good). 16. Volume and Atrophy (Geoff J.M. Parker and Declan T. Chard). 17. Shape and Texture (William R. Crum). 18. Histograms: Measuring Subtle Diffuse Disease (Paul S. Tofts, Gerard R. Davies and Jamshid Dehmeshki ). SECTION E: WHERE ARE WE GOING? 19. The Future of qMRI: Conclusions and Speculation (Paul S. Tofts). Appendix 1: Greek Alphabet for Scientific Use. Index.