Pharmacogenomics in Drug Discovery and Development

Qing Yan (Herausgeber)

Buch | Hardcover
487 Seiten
2008
Humana Press Inc. (Verlag)
978-1-58829-887-4 (ISBN)

Lese- und Medienproben

Pharmacogenomics in Drug Discovery and Development -
149,79 inkl. MwSt
This comprehensive volume explores cutting-edge technologies used to pursue systems-based pharmacogenomics. Extensive chapters follow on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases.
Since each human is genetically distinctive, responding differently to disease-causing factors as well as drugs, the field pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body. In Pharmacogenomics in Drug Discovery and Development, leading experts present methodical, state-of-the-art contributions covering topics from individual molecules to systemic diseases, examining both fundamental concepts and advanced technologies. Divided into three sections, the volume begins by exploring cutting-edge technologies used to pursue systems-based pharmacogenomics, followed by extensive chapters on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases.


Comprehensive and up-to-date, Pharmacogenomics in Drug Discovery and Development is an ideal volume for scientists striving to transform disease treatment into disease prevention.

The Integration of Personalized and Systems Medicine.- Applications of Microarrays and Biochips in Pharmacogenomics.- Confounding in Genetic Association Studies and Its Solutions.- Pharmacogenetics of Membrane Transporters.- Pharmacogenomics of Drug-Metabolizing Enzymes and Drug Transporters in Chemotherapy.- Pharmacogenomics of G Protein-Coupled Receptor.- G Protein-Coupled Receptors Disrupted in Human Genetic Disease.- G Protein-Coupled Receptor Pharmacogenetics.- Epigenetic Alterations of the Dopaminergic System in Major Psychiatric Disorders.- Pharmacogenomics in Alzheimer's Disease.- Pharmacogenetics of Asthma.- From SNPs to Functional Studies in Cardiovascular Pharmacogenomics.- Pharmacogenomics in Gastrointestinal Disorders.- Pharmacogenomics in Rheumatoid Arthritis.- Cancer Pharmacogenetics.- Pharmacogenomics in the Preclinical Development of Vaccines.- Pharmacogenomics in the Evaluation of Efficacy and Adverse Events During Clinical Development of Vaccines.

Reihe/Serie Methods in Molecular Biology ; 448
Zusatzinfo XIII, 487 p.
Verlagsort Totowa, NJ
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Pharmazie
Medizin / Pharmazie Studium
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Chemie Physikalische Chemie
Technik
ISBN-10 1-58829-887-6 / 1588298876
ISBN-13 978-1-58829-887-4 / 9781588298874
Zustand Neuware
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