Medicinal Applications of Coordination Chemistry

Honorary Visiting Professor in Radiochemistry, University of Manchester

Preface;

Chapter 1: INTRODUCTION;

1.1: METALS IN MEDICINE - A HISTORICAL PERSPECTIVE;

1.2: METALS AND HUMAN BIOCHEMISTRY;

1.3: METALLOPHARMACEUTICALS;

1.4: THE SPECIAL PROPERTIES OF METALS;

Chapter 2: THE CHEMISTRY OF METALS IN A NUTSHELL;

2.1: THE STRUCTURE OF MATERIALS;

2.2: THE STRUCTURES AND PROPERTIES OF ATOMS;

2.3: THE FORMATION OF COMPOUNDS;

2.4: THE CHEMISTRY OF METALS - AN OVERVIEW;

2.5: BONDING IN METAL COMPLEXES;

2.6: THE MAGNETISM AND SPECTROSCOPY OF METAL COMPLEXES;

2.7: THE ENERGETICS OF METAL COMPLEX FORMATION;

2.8: REACTIONS AT METAL CENTRES;

2.9: REDOX POTENTIALS;

2.10: CONCLUSIONS;

Chapter 3: DIAGNOSTIC MEDICINE;

3.1: INTRODUCTION;

3.2: ANATOMICAL IMAGING;

3.3: FUNCTIONAL IMAGING;

3.4: In vitro APPLICATIONS;

Chapter 4: THERAPEUTIC MEDICINE;

4.1: THE USE OF METAL COMPOUNDS IN THERAPY;

4.2: CHELATION THERAPY;

4.3: CANCER THERAPY;

4.4: RHEUMATOID ARTHRITIS;

4.5: DIABETES;

4.6: CARDIOVASCULAR SYSTEM;

4.7: THERAPEUTIC RADIOPHARMACEUTICALS;

Chapter 5: METALLOPHARMACEUTICAL DESIGN;

5.1: INTRODUCTION;

5.2: STRUCTURE ACTIVITY RELATIONSHIPS;

5.3: FUTURE DIRECTIONS