Sphingolipid Biology

Part 1: Overview.- Sphingolipids Synthesis, Transport and Cellular Signaling Serine Palmitoyltransferase.- Part 2: Biosynthesis, Transport of Sphingolipids.- Serine Palmitoyltransferase.- Ceramide Synthase.- Dihydroceramide: Sphinganine D 4-Desaturase and C4-Hydroxylase.- Metabolizing Enzymes Such As Sphingomyelin Synthase Induce Cell Death by Increasing Ceramide Content.- Glucosylceramide and Galactosylceramide Synthase.- Synthesis, Metabolism, and Trans-Bilayer Movement of Long-Chain Base.- Molecular Mechanism of Ceramide Trafficking from the Endoplasmic Reticulum to the Golgi Apparatus in Mammalian Cells.- Sphingolipid Trafficking.- Current Perspectives on Saccharomyces cerevisiae Sphingolipids.- Part 3: Generation and Degradation of Sphingolipid Signaling Molecules.- Generation of Signaling Molecules by de novo Sphingolipid Synthesis.- Overview of Acid and Neutral Sphingomyelinases in Cell Signaling.- Neutral Ceramidase as an Integral Modulator for the Generation of S1P and S1P-Mediated Signaling.- Activation of Sphingosine Kinase 1.- Ceramide 1-Phosphate.- Sphingosine-1-Phosphate Lyase.- Part 4: Membrane Domain and Biological Function.- Close Interrelationship of Sphingomyelinase and Caveolin in Triton X-100-Insoluble Membrane Microdomains.- Roles of Membrane Domains in the Signaling Pathway for B Cell Survival.- The Role of Lipid Rafts in Axon Growth and Guidance.- Sphingolipids and Multidrug Resistance of Cancer Cells.- Part 5: Membrane Lipid Domain and Human Pathobiology.- A New Pathological Feature of Insulin Resistance and Type 2 Diadetes: Involvement of Ganglioside GM3 and Membrane Microdomains.- Neuronal Cell Death in Glycosphingolipidoses.- Endocytic Trafficking of Glycosphingolipids in Sphingolipidoses.- Ganglioside and Alzheimer’s