ESMO Handbook on Principles of Translational Research

Presents the principles of cell biology, cellular pathways, and their implications for drug development in oncology.

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Using state-of-the-art and evidence-based literature references and reviews, the authors present an overview of translational research that is both reliable and easily understood. The book begins with principles of normal cell biology and normal immunology. It examines tumor biology and basic tumor immunology. It then discusses limitless replicative potential, self-sufficiency in growth signals, insensitivity to anti-growth signals, and evading apoptosis. The book concludes with a chapter on angiogenesis, tissue invasion and metastasis, treatment, and evaluation of treatment.