Cholecystokinin

Professor Christine Feinle-Bisset has a PhD in Nutrition and GI Physiology from the University of Stuttgart-Hohenheim, Germany. After gaining research experience at the University of Sheffield, UK and the University of Zurich, Switzerland, she joined the University of Adelaide in 2000, where she is currently a Professorial Research Fellow and a lead investigator in the Centre of Research Excellence in Translating Nutritional Science to Good Health. Her research is clinical and relates to the impact of nutrients on appetite, GI motor and hormone function and perception, in health, obesity and functional dyspepsia. Her work has contributed significantly to current concepts of the role of gastrointestinal mechanisms, including gut hormones and gastrointestinal motor activity, in the regulation of energy intake in health and obesity, and symptom generation in functional dyspepsia. She has published more than 220 publications, with over 15,000 citations. Professor Jens F. Rehfeld has an MD from the University of Aarhus, and later DMSc and DSc in Clinical Biochemistry from the University of Copenhagen. He became professor in Medical Biochemistry at University of Aarhus in 1975, and of Clinical Biochemistry, University of Copenhagen, in 1981. He was also administrative head of the Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, until 2010. His main research theme is bioactive peptides (in particular gastrin, cholecystokinin, and insulin), their biosynthesis, methods for measurement, and clinical relevance. He has published approximately 1100 publications, including 650 original articles, 90 review articles, 55 textbook chapters, and 8 books, and has more than 43,000 citations.

Part I - History 1. Milestones in the CCK history Jens F. Rehfeld and Christine Feinle-Bisset Part II - Biology of CCK 2. Evolutionarily conserved roles of cholecystokinin signaling Dick Nässel and Shunfan Wu 3. The biogenesis and cell-specific expression of cholecystokinin peptides Jens F. Rehfeld and Christine Feinle-Bisset 4. Cholecystokinin in intestinal and extraintestinal endocrine cells Frank Reimann, Fiona Gribble, and Marta Santoz Hernandez 5. Cholecystokinin in the central and peripheral nervous system Tomas Hökfelt 6. Cholecystokinin 1 and 2 receptors Larry Miller 7. The relationship between cholecystokinin and gastrin Jens F. Rehfeld Part III - Physiology of CCK 8. Intestinal cholecystokinin secretion Rodger A. Liddle 9. Cholecystokinin and the gut-brain axis Kirsteen Browning and Amanda Page



Cholecystokinin and the gallbladder

Ad Masclee 11. Cholecystokinin and the exocrine pancreas John Williams 12. Islet effects of cholecystokinin and exploitation in diabetes Nigel Irwin and Peter Flatt 13. Cholecystokinin and gastrointestinal motor function Christine Feinle-Bisset, Javad Anjom Shoae and Michael Horowitz 14. Effect of cholecystokinin on food intake and appetite Frank Duca 15. Cholecystokinin, nutrient preference and taste aversion Fiona Gribble, Frank Reimann, and Jo Lewis 16. Cholecystokinin in peripheral and central cardiovascular control Tony Verberne 17. Cholecystokinin in cardiac myocytes Jens P. Goetze Part IV – Methods used for CCK research 18. Measurement of cholecystokinin in biological fluids Jens F. Rehfeld and Jens P. Goetze 19. Cholecystokinin knockout mice: peripheral and central phenotypes Patrick Tso and Chunmin Lo Part V - CCK in disease 20. Cholecystokinin in obesity and other disorders of eating Tim Moran and Kimberly Smith 21. Cholecystokinin in tumors Jens F. Rehfeld 22. Cholecystokinin and panic disorder Jacques Bradwejn 23. Cholecystokinin and the immune system John Worthington 24. Cholecystokinin in nociception and pain Sascha Alles and Nesia Zurek Part V – CCK-based novel therapeutic approaches 25. Potential therapeutics targeting cholecystokinin 1 receptors Larry Miller Part VI - Conclusion 26. Reflections on cholecystokinin research - past, present and future Jens F. Rehfeld and Christine Feinle-Bisset