Smad Signal Transduction

Molecular Evolution of Smad Proteins.- C. Elegans TGF-? Signaling Pathways.- Smads In Drosophila – Interpretation Of Graded Signals In Vivo.- Delineating the TGF-?/Smad-Induced Cytostatic Response.- Smads In Mesenchymal Differentiation.- Smad Proteins in Apoptotic and Survival Signaling.- TGF-?/SMAD Signaling in Epithelial to Mesenchymal Transition.- Genetic Disruptions within the Murine Genome Reveal Numerous Roles of the Smad Gene Family in Development, Disease, and Cancer.- Trafficking of Serine/Threonine Kinase Receptors and Smad Activation.- Nucleocytoplasmic Shuttling of Smad Proteins.- Structural Insights into Smad Function and Specificity.- Regulation of Smad Function by Phosphorylation.- Regulation of Smad Functions Through Ubiquitination and Sumoylation Pathways.- Smad Transcriptional Co-Activators and Co-Repressors.- Integration of Signaling Pathways Via Smad Proteins.- Interplays Between The Smad and Map Kinase Signaling Pathways.- Gene Expression Signatures of TGF-?/Smad-Induced Responses.- Systems Biology Approaches to TGF-?/Smad Signaling.- Inhibitory Smads: Mechanisms of Action and Roles in Human Diseases.- Alterations in Smad Signaling in Carcinogenesis.- TGF-? Receptor Kinase Inhibitors for the Treatment of Cancer.- TGF-? Receptor Kinase Inhibitors for Treatment of Fibrosis.