Principles of Protein X-Ray Crystallography

(Autor)

Buch | Hardcover
332 Seiten
2006 | 3rd ed. 2007
Springer-Verlag New York Inc.
978-0-387-33334-2 (ISBN)

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Principles of Protein X-Ray Crystallography - Jan Drenth
117,69 inkl. MwSt
In this new edition of an essential work, the renowned researcher Dr. Jan Drenth offers a rigorous and up-to-date introduction to the subject, providing the theoretical background necessary to understand how the structure of proteins is determined at atomic resolution.
X-ray crystallography is an established method for studying the structure of proteins and other macromolecules. As the importance of proteins grows, researchers in many fields have found that a working knowledge of X-ray diffraction is an indispensable tool. In this new edition of his essential work, the internationally recognized researcher Dr. Jan Drenth offers an up-to-date and technically rigorous introduction to the subject, providing the theoretical background necessary to understand how the structure of proteins is determined at atomic resolution. New material in the 3rd edition includes a section on twinning, an additional chapter on crystal growth and a discussion of single-wavelength anomalous dispersion.

Dr. Jan Drenth is a professor emeritus at the Laboratory of Biophysical Chemistry at the University of Groningen, The Netherlands. Contributing author Dr. Jeroen R. Mesters Ph.D. is a Senior Research Assistant at the Institute of Biochemistry, University of Luebeck, Germany.

Crystallizing a Protein.- X-ray Sources and Detectors.- Crystals.- Theory of X-ray Diffraction by a Crystal.- Average Reflection Intensity and Distribution of Structure Factor Data.- Special Forms of the Structure Factor.- The Solution of the Phase Problem by the Isomorphous Replacement Method.- Phase Improvement.- Anomalous Scattering in the Determination of the Protein Phase Angles and the Absolute Configuration.- Molecular Replacement.- Direct Methods.- Laue Diffraction.- Refinement of the Model Structure.- The Combination of Phase Information.- Checking for Gross Errors and Estimating the Accuracy of the Structural Model.- Practical Protein Crystallization.

Reihe/Serie Springer Advanced Texts in Chemistry
Zusatzinfo XIV, 332 p.
Verlagsort New York, NY
Sprache englisch
Maße 155 x 235 mm
Themenwelt Naturwissenschaften Biologie Biochemie
Naturwissenschaften Geowissenschaften Mineralogie / Paläontologie
ISBN-10 0-387-33334-7 / 0387333347
ISBN-13 978-0-387-33334-2 / 9780387333342
Zustand Neuware
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