T.Cell Receptors
Oxford University Press (Verlag)
978-0-19-262419-2 (ISBN)
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T cell receptors covers biochemical, functional and genetic aspects of this key family of immunological molecules. It should be essential reading for all those interested in the TCR and its function in health and disease. It deals with the TCR protein, its functional interactions with the signal transduction machinery of the T cell and with the structure and organisation of the TCR genes. It is the only comprehensive volume on the TCR and is written by leaders in the field. Particularly useful is the tabulation and nomenclature of all the known TCR alpha and beta variable regions. This book is intended for any specialist researcher interested in T cells. All postgraduate immunologists.
Introduction: Historical overview. 1: Development of T cells in the thymus. 2: The function of aBT cells and the role of the co-receptor molecule, CD4 and CD8. 3: T cell specificity and function. 4: Emergence of the T cell receptor repertoire. 5: The human T cell receptor repertoire. 6: T cell activation. 7: Transgenesis and the T cell receptor. 8: Superantigens and tolerance. 9: Src - related kinases and their receptors in T cell activation. 10: Organisation of the human TCRB gene complex. 11: Genomic organisation of T cell receptor genes in the mouse. 12: Nature of variation among variable genes. 13: T cell receptor V(D)J recombination: Mechanisms and developmental regulation. 14: Allelic exclusion of T cell antigen receptor genes. 15: Plasticity of the TCR/CD3 complex. 16: The immune recognition unit: The TCR/peptide/MHC complex. 17: A structural model of a bacterial superantigen binding to MHC class II and T cell receptors. 18: Biosynthesis of MHC products and its relevance for antigen presentation. Appendix A1 - Nomanclative. Appendix A2 - Sequences
| Erscheint lt. Verlag | 31.10.1995 |
|---|---|
| Co-Autor | Michael J. Owen, Elizabeth Simpson |
| Zusatzinfo | 6 colour plates; halftones, line figures, tables, bibliography |
| Verlagsort | Oxford |
| Sprache | englisch |
| Maße | 150 x 230 mm |
| Gewicht | 760 g |
| Themenwelt | Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| Studium ► Querschnittsbereiche ► Infektiologie / Immunologie | |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| ISBN-10 | 0-19-262419-9 / 0192624199 |
| ISBN-13 | 978-0-19-262419-2 / 9780192624192 |
| Zustand | Neuware |
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