p53 in Breast Cancer

Dr. Manzoor Ahmad Mir is presently working as a scientist and head of department at the Department of Bioresources, University of Kashmir. He holds master’s degree in Zoology with Gold Medal from HNBG Central University and got his Ph.D. from Jawaharlal Nehru University New Delhi and CSIR-Institute of Microbial Technology, Chandigarh, in the field of Immunopathology. His research interest is cancer biology with specialization in drug repurposing and combination therapy of breast cancer and to elucidate the molecular mechanism behind it, besides use of natural agents in treating cancer. He is also working on expression pattern and prognostic significance of chemokines/cytokines of CDKs in breast cancer, as well as the virtual screening of drugs for cancer treatment and their mechanistic elucidation. He has published more than 50 high-impact research papers and book chapters, in recognition of which he has received several awards. Dr. Manzoor has authored more than 16 books with international publishers. He is on the editorial board and reviewer of some prestigious journals and has been an invited speaker at various scientific meetings/conferences within India and abroad. He is member of many scientific organizations and societies, like American Association of Cancer Research, the Royal British Society, American Association of Clinical Oncology, International Immunology Association, etc. Dr Manzoor was awarded Teachers Associate Research Excellence Fellowship (TARE) by DST Govt of India and Summer Research Fellowship Programme (SRFP-2019) by Indian Academy of Sciences and National Science Academy. Dr Manzoor has developed Massive Open Online Course (MOOCs) in immunology, human genetics, and endocrinology for UG students sanctioned by UGC-Consortium for Educational Communication (CEC) SWAYAM Ministry of HRD Govt of India. He has research and teaching experience of 15 years in cancer biology, animal cell and tissue technology, molecular modelling and drug design, comparative immunology.

Chapter 1: Role of p53 in Cancer Metabolism Chapter 2: Exploring the Intricacies of p53 and its Connection to Breast Cancer Chapter 3: P53 Pathways in the Progression of Breast Cancer Chapter 4: Mutational Alterations in p53: Their Impact on the Development of Breast Cancer Chapter 5: P53 and Cell Death Regulation: Managing Apoptosis in Breast Cancer Chapter 6: The Contribution of p53 to DNA Repair and Genomic Stability in Breast Cancer Chapter 7: Interaction of Mutant p53 with Transcription Factors and DNA Repair Enzymes Chapter 8: P53 Control of Cell Cycle Dynamics in Breast Cancer: Maintaining a Balance Between Proliferation and Arrest Chapter 9: The Complex Interplay Between Mutant p53, p63, and p73, and Their Effect on Cellular Processes Chapter 10: Role of Post-Translational Modifications in Regulation of Mutant p53 Chapter 11: Genetic Alterations Affecting p53 and Emerging Perspectives on Epigenetic Control of p53 in Breast Cancer Chapter 12: Targeted Therapies Against Mutated p53 in Breast Cancer Chapter 13: The Mevalonate Pathway's Involvement in Cancer Progression in the Context of Mutant p53 Chapter 14: Interactions and Implications of p53 in Hormonal Signaling Pathways in Breast Cancer Chapter 15: p53 as a Diagnostic Biomarker in Breast Cancer Chapter 16: The Impact of Nutrition on p53 Activity: Implications for Preventing and Treating Breast Cancer Chapter 17: The Interplay Between p53 and the Tumor Microenvironment in Progressing Breast Cancer Chapter 18: Current State and Future Avenues of p53 Gene Therapy in Breast Cancer Chapter 19: Insights from Genetic Studies: The Role of p53 in Hereditary Breast Cancer Syndrome Chapter 20: Bridging Bench to Bedside in Breast Cancer Therapy: Translational Insights into p53 Research.