Tic Disorders and Tourette Syndrome

Dr. Ganos completed medical training at the University Medical center in Hamburg-Eppendorf in Germany, and undertook a three-year fellowship at the National Hospital for Neurology and Neurosurgery at the Clinical Movement Disorders Group of Prof. Kailash Bhatia. Dr. Ganos is an adult neurologist in the university clinic of Charité in Berlin and currently sees patients of all ages with movement disorders with a particular focus in hyperkinetic and unusual or rare movement disorders. He leads the Movement Disorders and Body Control lab within the Movement Disorders and Neuromodulation Unit of Prof. Andrea Kühn. Dr. Ganos research primarily focuses on hyperkinetic movement disorders, such as Tourette syndrome and Dystonia and he is currently a “Freigeist” Fellow of the VolkswagenStiftung. Within the field of tic disorders, Dr. Ganos is interested in the pathophysiology of tics and premonitory urges with the particular scope of developing novel treatment methods. He is the chair of the International Parkinson’s Disease and Movement Disorder Society’s Tic Disorders and Tourette Syndrome study group, a past secretary of the European Society for the Study of Tourette Syndrome and an invited panel member of the German Academy of Rare Neurological Diseases. Yulia Worbe graduated from the Medical University of St. Petersburg in Russia, with a PhD from Sorbonne Univ in France. She is at Sorbonne University and Saint-Antoine Hospital, France as a lecturer and practitioner, focusing on abnormal movements.

Introduction
1. Introduction
2. History of Tic Disorders and Tourette Syndrome
3. Clinical Description of Primary Tics
4. Secondary Tics
5. Functional Tics
6. Habits, Stereotypies, Mannerisms

Comorbidities in primary tic disorders
7. OCD in primary tic disorders and Tourette syndrome
8. ADHD in primary tic disorders and Tourette syndrome
9. Intermittent Explosive Disorders
10. Mood disorders
11. Sleep disorders in primary tic disorders and Tourette syndrome
12. Other neurodevelopmental disorders
13. Sexual health and sexuality in Tourette disorders

Etiology and Pathophysiology
14. Epidemiology
15. Genetics
16. Neurodevelopmental aspects: Brain development, deviation from trajectory etc
17. Neuroimmunology
18. Animal models of tic disorders: Izhar Bar-Gad and Leon Tremblay?
19. Clinical Neurophysiology of Tics
20. Neuroimaging of tic disorders
21. Dopamine and other neurotransmitters
22. Premonitory urges and other sensory phenomena in primary tic disorders
23. Action inhibition and inhibitory tic control

Treatments
24. Behavioral Treatments
25. Pharmacological Treatments
26. Invasive neuromodulation
27. Non-invasive neuromodulation
28. Treatment of neuropsychiatric comorbidities in tic disorders
29. Overview of patient organizations and other useful resources
30. Closing remarks and future scope of unmet needs