The Biology of Disease (eBook)

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2024 | 3. Auflage
1314 Seiten
Wiley (Verlag)
978-1-119-42635-6 (ISBN)

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All-new edition of a classic textbook bridging the gap between human biology and clinical practice

The Biology of Disease provides a comprehensive overview of the principles of the disease process. Building on the success of previous editions, this all-new Third Edition reflects the unprecedented challenges that the global community now faces in the field, as well as advances in the basic sciences of cell biology, immunology, and the molecular mechanisms of disease, with all chapters extensively modified to ensure that they remain at the cutting edge of current knowledge.

Each section is followed by case studies which bridge the gap between theory and clinical practice. This Third Edition includes 72 case studies in total, of which 34 are new. All diagrams and figures have been updated to present the most relevant information at a glance, and a new companion website with more than 500 multiple choice questions in two difficulty levels has been made available.

Written by three highly qualified academics with significant experience in the field, The Biology of Disease includes information on:

  • Emergence of new and drug resistant pathogens and an increasing recognition of the environmental factors, including climate change, that influence health
  • The growing impact of diet and physical inactivity on the development of obesity and related disorders including cancer and type 2 diabetes
  • Principles of epidemiology, cell reproduction, injury and death, inflammation and disorders of immunity
  • Disorders of blood and blood vessels including anaemia, vascular disorders, and disorders of haemostasis

The Biology of Disease is an essential textbook resource for medical students with a focus in physiology, pathophysiology, or pharmacology, along with undergraduate students in biomedical science, biomedicine, medical biochemistry, and human biology.

Prof. Paul G. Murray, Department of Pathology, Royal College of Surgeons in Ireland-Medical, University of Bahrain. Professor of Molecular Pathology at University of Limerick, Ireland, and Honorary Professor, University of Birmingham, United Kingdom.

Dr. Simon J. Dunmore, Honorary Clinical Senior Lecturer, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen; Honorary Lecturer, Cardiovascular Sciences, School of Medicine, University of Edinburgh; NHS Scotland (Grampian).

Dr. Shantha Perera, Visiting Senior Lecturer, School of Life Sciences, University of Wolverhampton, United Kingdom.

List of Contributors


Numbers in [ ] denote authors of chapter or case study.

Ashraf Albishtawi
Medical Student,
Royal College of Surgeons in Ireland ‐ Medical
University of Bahrain, Busaiteen 228,
Bahrain [9,CS19,CS40,CS50]

Fatima AlHashimi
Consultant Histopathologist,
King Hamad University Hospital, Bahrain,
and Senior Clinical Lecturer, Royal College of
Surgeons in Ireland ‐ Medical University of
Bahrain [CS31,CS32]

Mohamed AlKhaja
Consultant Neurologist, Epileptologist and
Clinical Neurophysiologist,
King Hamad University Hospital,
Bahrain [CS15,CS25,CS56]

Jumana Turky K. Alrujaib
Medical Student,
Royal College of Surgeons in Ireland ‐ Medical
University of Bahrain, Busaiteen 228,
Bahrain [CS15,CS25]

Rawaa Alsayegh
Clinical Educator in Medicine,
Royal College of Surgeons in Ireland ‐ Medical
University of Bahrain, Busaiteen 228,
Bahrain [9,CS10,CS12,CS13,CS14,CS18,CS20,
CS22,CS33,CS36,CS40,CS54,CS55,CS57,CS58,
CS61,CS63,CS67,CS68]

Raja H. Alyusuf
Consultant Pathologist,
Department of Pathology, Salmaniya Medical
Complex, Kingdom of Bahrain and Royal
College of Surgeons in Ireland ‐ Medical
University of Bahrain,
Busaiteen 228, Bahrain [CS22]

Stephen Atkin
Head, School of Postgraduate Studies
and Research,
Royal College of Surgeons in Ireland ‐ Medical
University of Bahrain, Busaiteen 228,
Bahrain [13,CS70,CS71,CS72]

Shivani Bailey
Consultant in Paediatric Neuro‐oncology,
Birmingham Children’s Hospital and Senior
Clinical Research Fellow, Birmingham
Cancer Research UK Clinical Trials Unit,
University of Birmingham,
United Kingdom [CS54]

David Burns
Consultant Haematologist,
University Hospitals Plymouth NHS
Trust, Derriford Road, Crownhill,
Plymouth, Devon,
United Kingdom [CS33]

Alexandra E. Butler
Professor in Pathology,
Royal College of Surgeons in Ireland ‐ Medical
University of Bahrain, Busaiteen 228,
Bahrain [13,CS70,CS71,CS72]

Hiu Kwan Carolyn Tang
Consultant Medical Oncologist,
Cambridge University NHS Foundation Trust,
Cambrdige, United Kingdom [CS51]

Dimitrios Chanouzas
Consultant Nephrologist,
Queen Elizabeth Hospital Birmingham,
Mindelsohn Way, Edgbaston, Birmingham,
United Kingdom [CS31,CS32]

Amen EL Cheikh Ammar
Consultant Pulmonologist and Senior
Lecturer, Royal College of Surgeons in
Ireland ‐ Medical University of Bahrain
Busaiteen 228, Bahrain [CS2,CS27,CS69]

Ruth Clifford
Consultant Haematologist, University
Hospital Limerick, Clinical Professor, GEMS,
University of Limerick Hospitals Group,
University Hospital Limerick,
Ireland [CS16,CS52,CS55,CS57,CS58,
CS62,CS67]

Pippa G. Corrie
Consultant and Affiliated Associate Professor
in Medical Oncology,
Cambridge University Hospitals NHS
Foundation Trust and University of
Cambridge, United Kingdom [CS51,CS68]

Simon J. Dunmore
Honorary Clinical Senior Lecturer,
School of Medicine, Medical Sciences
and Nutrition,
University of Aberdeen; Honorary Lecturer,
Cardiovascular Sciences, School of Medicine,
University of Edinburgh; NHS Scotland
(Grampian) [12,13,CS70,CS71,CS72]

Kevin Dunne
Professor of Paediatrics,
Royal College of Surgeons in Ireland ‐ Medical
University of Bahrain, Busaiteen 228,
Bahrain [CS43]

J. David M. Edgar
Consultant Immunologist, St. James’s Hospital
and Trinity College, Dublin, Ireland
[6,CS20,CS23,CS30,CS31,CS33,CS39]

Éanna Fennell
Irish Research Council Postdoctoral Fellow,
Limerick Digital Cancer Research Centre,
School of Medicine, Bernal Institute and
Health Research Institute, University of
Limerick, Limerick,
Ireland [CS11,CS57]

Fidelma Fitzpatrick
Professor and Head of Department of
Clinical Microbiology, RCSI and Consultant
Microbiologist, Beaumont Hospital, Dublin,
Ireland [CS9,CS12,CS13]

Siobhan Glavey
Professor and Head of the Department of
Pathology, RCSI, Dublin, and Consultant
Haematologist,
Department of Haematology Beaumont
RCSI Cancer Centre, Dublin,
Ireland [CS16,CS62]

Alexander Glover
Clinical Research Fellow, Institute of
Immunology and Immunotherapy,
University of Birmingham
Birmingham,
United Kingdom [CS63]

Kate Glover
Principal Clinical Scientist,
Birmingham Women's and Children's NHS
Foundation Trust,
Mindelsohn Way, Birmingham,
United Kingdom [10,CS41,CS42,CS44,CS45,
CS46,CS49]

Lorraine Hartles‐Spencer
Principal Clinical Scientist,
West Midlands Regional Genetics Laboratory,
Birmingham Women’s Hospital,
Mindelsohn Way, Birmingham [10]

Jamal Hasan Hashem
Lecturer in Surgery, and Academic Director of
Artificial Intelligence,
Royal College of Surgeons in Ireland ‐ Medical
University of Bahrain, Busaiteen 228,
Bahrain [CS10,CS17,CS28,CS38]

Eddie Jones
University Hospital Limerick,
St. Nessan’s Road,
Dooradoyle, Limerick, Ireland [CS47,CS48]

Nadira D. Karunaweera
Chair and Senior Professor of Parasitology,
Department of Parasitology,
Faculty of Medicine,
University of Colombo,
Sri Lanka [4,CS5,CS7,CS8]

Catherine King
Renal Research Fellow,
Institute of Immunology and Immunotherapy,
University of Birmingham, Cancer Sciences
Building, Edgbaston,
Birmingham [CS31,CS32]

Nitya Kumar
Senior Lecturer in Public Health and
Epidemiology,
Royal College of Surgeons in Ireland ‐ Medical
University of Bahrain, Bahrain [2]

Daniela Kurfürstová
Department of Clinical and Molecular
Pathology, Palacky University and University
Hospital Olomouc,
Czech Republic [CS66]

Ciara Leahy
Irish Research Council PhD Student,
Limerick Digital Cancer Research Centre,
School of Medicine, Bernal Institute and
Health Research Institute, University of
Limerick, Limerick, Ireland [CS63]

Mary Lynch Al Tarief
Consultant Cardiologist,
Mohammed Bin Khalifa Bin Salman
AlKhalifa Cardiac Center, Adjunct
Professor of Medicine, Royal College of
Surgeons in Ireland ‐ Medical University
of Bahrain, Busaiteen 228,
Bahrain [CS35,CS36,CS37,CS40]

Laila Ayelet Mizrahi
Medical Student,
Royal College of Surgeons in Ireland ‐ Medical
University of Bahrain, Busaiteen 228,
Bahrain [CS4,CS36,CS44]

Sara Mohamed
Clinical Educator in Medicine,
Royal College of Surgeons in Ireland ‐ Medical
University of Bahrain, Busaiteen 228,
Bahrain [CS9,CS21,CS26,CS40,CS59]

Fatima Moh'D Muhsen Khader Atieh
Medical Student,
Royal College of Surgeons in Ireland ‐ Medical
University of Bahrain, Busaiteen 228,
Bahrain [CS12,CS21,CS30,CS32,CS35,CS36,
CS39,CS59]

Paul G. Murray
Professor of Pathology and Head of the
Department of Pathology,
Royal College of Surgeons in Ireland ‐ Medical
University of Bahrain,
Professor of Molecular Pathology,
University of Limerick, Ireland, and Honorary
Professor, University of Birmingham,
United Kingdom [1,3,4,5,6,7,8,9,10,11,14,CS1,
CS3,CS4,CS5,CS6,CS7,CS10,CS11,CS12,CS15,
CS16,CS17,CS18,CS19,CS21,CS24,CS25,CS26,
CS27,CS28,CS31,CS32,CS35,CS36,CS37,CS38,
CS39,CS43,CS44,CS50,CS52,CS54,CS55,CS56,
CS57,CS58,CS59,CS60,CS61,CS62,CS63,CS64,
CS65,CS68,CS69]

Shantha Perera
Visiting Senior Lecturer,
School of Life Sciences,
University of Wolverhampton,
United Kingdom [6,CS3]

Niamh Peters
Consultant Medical Oncologist,
University of Limerick Hospitals Group,
University Hospital Limerick,
St. Nessan’s Road,
Dooradoyle, Limerick, Ireland [CS41,CS53,
CS59,CS60,CS61,CS66]

Matthew Pugh
Jean Shanks / Pathological Society
Intermediate Clinical Fellow, Associate
Clinical Professor, Honorary Consultant
Histopathologist,
University Hospitals Birimingham
Foundation Trust [CS3,CS11,CS55,CS57,
CS63,CS67,CS68]

Sara Bashar Qasrawi
Medical Student,
Royal College of Surgeons in Ireland ‐ Medical
University of Bahrain, Busaiteen 228,
Bahrain [CS21]

Denis S. Quill
Associate Professor in Surgery, Department
of Surgery, Royal College of Surgeons in
Ireland ‐ Medical University of Bahrain,
Busaiteen 228, Bahrain [CS50]

Sara Mohammed Ahmed Rady
Medical Student,
Royal College of Surgeons in Ireland ‐ Medical
University of Bahrain, Busaiteen 228, Bahrain
[CS20,CS22,CS37,CS38]

Aisling Ross
Marie Skłodowska‐Curie Actions
Research Fellow,
Bernal Institute and School of Medicine,
University of Limerick, Ireland, and Walter
and Eliza Hall Institute of...

Erscheint lt. Verlag 1.8.2024
Sprache englisch
Themenwelt Naturwissenschaften Biologie Mikrobiologie / Immunologie
Schlagworte blood disorders • Cancer • Cardiovascular Disease • causes of obesity • cell death • Cell Injury • cell reproduction • drug resistant pathogens • epidemiology • Genetic disorders • immunity • Infectious Diseases • inflammation • Metabolic disease
ISBN-10 1-119-42635-9 / 1119426359
ISBN-13 978-1-119-42635-6 / 9781119426356
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