Basics of Hematopoietic Stem Cell Transplant

Sanjeev Kumar Sharma has done MBBS and MD (Medicine) from University College of Medical Sciences, Guru Teg Bahadur Hospital, New Delhi. He received gold medal for best thesis in MD (Medicine). During his senior residency from Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, he developed keen interest in hematology. He did his DM (Clinical Hematology) from the prestigious All India Institute of Medical Sciences (AIIMS), New Delhi. He worked as Senior Consultant and Head of the Department in the Department of Hemato-oncology and Bone Marrow Transplantation at BLK-MAX Superspeciality Hospital, New Delhi. Currently he is heading the Department of Hemato-oncology and Bone Marrow Transplantation at Venkateshwar Hospital, Dwarka, New Delhi. He has a vast experience in hematopoietic stem cell transplants spanning over 15 years. He has special interest in the management of hematological malignancies and hematopoietic stem cell transplantation. He has more than 70 publications in peer-reviewed national and international journals and chapters in books. He is also the reviewer for various journals. He is also the author of the best selling hematology multiple choice questions book for medical graduates and hematology residents preparing for various entrance exams titled – MCQs in Hematology. He is a great teacher and has trained DNB students, Fellows and Registrars in clinical hematology and hematopoietic stem cell transplantation. Dr Sharma has also received the Best Citizen of India Award. The current book – Basics of Hematopoietic Stem Cell Transplantation – is intended for young hematologists and transplant Fellows who have started learning stem cell transplantation and face difficulties related to stem cell transplantation. This is a question and answer-based book and covers nearly all aspects of hematopoietic stem cell transplantation.

Section1-introduction to the basics of stem cell transplant and t cells.- history of stem cell transplant.- basics of stem cell transplant.- hematopoiesis.- t cell development-1.- t cell development-2.- role of thymus.- immunology of stem cell transplant.- early t precursor cell.- regulatory t cells.- tolerance induction.- section 2: b cells and dendritic cells.- b cells.- dendritic cells.- section 3: diseases of t cells.- t cell malignancies.- primary immunodeficiency diseases.- section 4: pre-transplant procedures.- apheresis.- cryopreservation.- section 5: radio-chemotherapeutic agents used in stem cell transplant.- classification of conditioning regimens.- chemotherapeutic agents used in stem cell transplant.- role of anti-thymocyte globulin in stem cell transplant.- total body irradiation.- section 6: autologous stem cell transplant.- indications for autologous stem cell transplant.- stem cell transplant for autoimmune diseases.- stem cell transplant for hodgkin lymphoma.- stem cell transplant for b cell non-hodgkin lymphoma.- stem cell transplant for t cell non-hodgkin lymphoma.- stem cell transplant for plasma cell dyscrasias.- section 7: allogeneic stem cell transplant.- indications allogeneic stem cell transplant.- stem cell transplant for severe aplastic anemia.- stem cell transplant for hemoglobinopathies.- stem cell transplant for acute lymphoblastic leukemia.- stem cell transplant for acute myeloblastic leukemia.- stem cell transplant for myelofibrosis.- section 8: haploidentical stem cell transplant.- haploidentical stem cell transplant.- section 9: graft-versus-host disease.- acute gvhd.- chronic gvhd.- section10: post transplant monitoring and management.- immune reconstitution following stem cell transplant.- drugs used post stem cell transplant.- chimerism post stem cell transplant.- post transplant immunosuppression.- donor lymphocyte infusion.- adoptive t cell therapy.- section 11: infections post stem cell transplant.- bacterial infections poststem cell transplant.- clostridium difficile infection in stem cell transplant recipients.- cytomegalovirus infection post stem cell transplant.- fungal infections post stem cell transplant.- viral infections in patients undergoing chemotherapy and stem cell transplant.- pneumocystis jirovecii in patients undergoing chemotherapy and stem cell transplant.- section 12: complications post stem cell transplant.- complications in patients post stem cell transplant.- engraftment syndrome post stem cell transplant.- hemorrhagic cystitis post stem cell transplant.- sinusoidal obstruction syndrome in patients post stem cell transplant.- relapse following allogeneic stem cell transplant.- abo mismatched stem cell transplant and related complications.- cytopenias post stem cell transplant.- section 13: miscellaneous.- pre-transplant evaluation.- major histocompatibility complex.- vaccination post stem cell transplant.- hemophagocytic lymphohistiocytosis.- electrolyte management during stem cell transplant.- miscellaneous questions.