Nanotechnology in Therapeutics (eBook)
304 Seiten
Wiley (Verlag)
978-1-394-27407-9 (ISBN)
Nanotechnology in Therapeutics
Comprehensive reference delivering a framework to develop and assess nanosystems that provide unique advantages in biomedical applications
Nanotechnology in Therapeutics explores the idea that by studying in depth the behavior of living organisms, especially the functionality of their cell membranes, we can develop and evaluate innovative bio-inspired nanosystems that are able to deliver small molecules, biomolecules like proteins, peptides, and other genetic material in terms of the production of new therapies and vaccines. The main concept promoted in this book is an integrated approach for producing new medicines following the nanotoxicity, biotoxicity, regulatory, and ethical guidelines, which are also covered in the book.
The book is divided into three parts. Part A provides an introduction and a historical overview of nanotechnology. Part B delves deeper into issues relating to lipid and polymeric nanostructures in medicine. Part C presents the regulatory landscape around nanotechnology and nanomedicine, while highlighting the need to keep an eye on emerging technologies such as artificial intelligence and machine learning. Overall, this book opens up biomedical applications for previously challenging drugs and drug targets.
Written by a highly qualified professor with significant pertinent research experience, Nanotechnology in Therapeutics includes discussion on:
- Eukaryotic cell membranes, their structural properties, and the thermodynamic payload of their lipid bilayers
- The DLVO (Derjaguin, Landau, Verwey and Overbeek) theory as a scientific tool for studying the stability and the behavior of nanoparticles
- Liposomes, lipid nanoparticles, and solid lipid nanoparticles, as well as polymeric nanoparticles, like micelles, polymersomes, and dendrimers
- Issues in the approval process of nanomedicines by the regulatory agencies, such as complexity, chaos, and nonlinear dynamics
With comprehensive coverage of novel concepts that have the potential to transform how new medicines are designed and developed, Nanotechnology in Therapeutics is an essential resource on the subject for chemists in industry, as well as biomedical and pharmaceutical engineers.
Costas Demetzos is Professor of Pharmaceutical Nanotechnology at the National and Kapodistrian University of Athens. Currently, Prof. Demetzos serves as Director of the Laboratory of Pharmaceutical Technology, and since 2008 he serves as President of the Hellenic Pharmaceutical Society (HPS). His research interests include pharmaceutical nanotechnology, nanomedicine, and thermodynamics.
Nanotechnology in Therapeutics Comprehensive reference delivering a framework to develop and assess nanosystems that provide unique advantages in biomedical applications Nanotechnology in Therapeutics explores the idea that by studying in depth the behavior of living organisms, especially the functionality of their cell membranes, we can develop and evaluate innovative bio-inspired nanosystems that are able to deliver small molecules, biomolecules like proteins, peptides, and other genetic material in terms of the production of new therapies and vaccines. The main concept promoted in this book is an integrated approach for producing new medicines following the nanotoxicity, biotoxicity, regulatory, and ethical guidelines, which are also covered in the book. The book is divided into three parts. Part A provides an introduction and a historical overview of nanotechnology. Part B delves deeper into issues relating to lipid and polymeric nanostructures in medicine. Part C presents the regulatory landscape around nanotechnology and nanomedicine, while highlighting the need to keep an eye on emerging technologies such as artificial intelligence and machine learning. Overall, this book opens up biomedical applications for previously challenging drugs and drug targets. Written by a highly qualified professor with significant pertinent research experience, Nanotechnology in Therapeutics includes discussion on: Eukaryotic cell membranes, their structural properties, and the thermodynamic payload of their lipid bilayersThe DLVO (Derjaguin, Landau, Verwey and Overbeek) theory as a scientific tool for studying the stability and the behavior of nanoparticlesLiposomes, lipid nanoparticles, and solid lipid nanoparticles, as well as polymeric nanoparticles, like micelles, polymersomes, and dendrimersIssues in the approval process of nanomedicines by the regulatory agencies, such as complexity, chaos, and nonlinear dynamics With comprehensive coverage of novel concepts that have the potential to transform how new medicines are designed and developed, Nanotechnology in Therapeutics is an essential resource on the subject for chemists in industry, as well as biomedical and pharmaceutical engineers.
List of Abbreviations
- ACE2
- Angiotensin‐converting enzyme 2
- ADME
- Absorption distribution metabolism and excretion
- aDDnS
- Advanced drug delivery nanosystems
- AFM
- Atomic force microscopy
- APC
- Antigen presenting cells
- AI
- Artificial intelligence
- AIDS
- Acquired immunodeficiency syndrome
- ANN
- Artificial neural network
- ATMP
- Advanced therapy medicinal product
- ATP
- Adenosine triphosphate
- AuNR
- Gold nanorod
- BCD
- Biological complex drugs
- CAT
- Committee for Advanced Therapies
- CBER
- Center for Biological Evaluations and Research
- CDER
- Center for Drug Evaluation and Research
- CDRH
- Center for Device and Radiological Health
- c‐DOPE
- citraconyl‐DOPE (1,2‐dioleoyl‐3‐phosphatidylethanotamine)
- CHMP
- Committee for Medicinal Products for Human Use
- CLN
- Core–shell lipid nanoparticle
- CPP
- Critical packing parameter
- CRISPR
- Clustered regularly interspaced short palindromic repeats
- Cryo‐AFM
- Cryogenic atomic force microscopy
- Cryo‐TEM
- Cryo‐transmission electron microscopy
- CQAs
- Critical quality attributes
- CVD
- Cardiovascular disease
- CVM
- Center for Veterinary Medicine
- DAPE
- Diacetylenic phosphatidylethanolamine
- ΔCpmax
- Change of maximum heat capacity
- ΔΗ
- Change in enthalpic content
- ΔT1/2
- Change in transition's width at half peak height
- DLin‐MC3‐DMA
- (6Z,9Z,28Z,31Z)‐Heptatriaconta‐6,9,28,31‐tetraen‐19‐yl‐4‐(dimethyl‐amino)butanoate
- DLVO
- Derjaguin, Landau, Verwey, and Overbeek
- DL
- Deep learning
- DLS
- Dynamic light scattering
- DMA
- Dynamic mechanical analysis
- DMPC
- Dimyristoylphosphatidylcholine
- DMPG
- Dimyristoylphosphatidylglycerol
- DOPC
- Dioleoyl‐phosphatidylcholine
- DOPE
- Dioleoyl‐phosphatidylethanolamine
- DODMA
- 1,2‐Dioleyloxy‐3‐dimethylaminopropane
- DOTAP
- 1,2‐Dioleoyl‐3‐(trimethylammonium)‐propane
- DOTMA
- N‐1‐(2,3‐dioleoyloxy)‐propyl‐N,N,N‐trimethylammonium
- DPH
- Diphenylhexatriene
- DPPC
- Dipalmitoyl‐phosphatidylcholine
- DPPE
- Dipalmitoyl‐phosphatidylethanolamine
- DPPG
- Dipalmitoyl‐phosphatidylglycerol
- DQA
- Deqalinium
- DSPE‐PEG
- Distearoyl‐phosphatidylethanolamine‐polyethylene glycol
- DSPC
- Distearoyl‐phosphatidylcholine
- DSC
- Differential scanning calorimetry
- DT
- Digital therapeutic
- DTA
- Differential thermal analysis
- DTG
- Differential thermogravimetry
- EAPP
- European agency for pharmaceutical products
- EC
- European Commission
- EEA
- European Economic Area
- EFSA
- European Food Safety Authority
- EFTA‐EEA
- European Free Trade Associations‐European Economic Area
- EGA
- Evolved gas analysis
- EHF
- Ebola hemorrhagic fever
- ELS
- Electrophoretic light scattering
- EM
- Electronic microscopy
- EMA
- European Medicine Agency
- EMEA
- European Agency for the Evaluation of Medicinal Products
- EPAR
- European Public Assessment Report
- EPC
- Egg‐phosphatidylcholine
- EPR
- Enhanced permeability and retention
- ETP
- European technology platform
- ETPN
- European technology platform on nanomedicine
- EU
- European Union
- EVD
- Ebola virus disease
- FDA
- Food and Drug Administration
- FFEM
- Freeze fracture electron microscopy
- FF‐TEM
- Freeze‐fracture transmission electron microscopy
- FTIR
- Fourier transform infrared spectroscopy
- G
- Gibbs free energy
- GDPR
- General data protection regulation
- GI
- Gastrointestinal
- GMO
- Glyceryl monooleate
- GMP
- Good manufacturing practice
- GPI
- Glycosylphosphatidylinositol
- GTMP
- Gene therapy medicinal product
- GUV
- Giant unilamellar liposome
- HHV
- Human herpes virus
- HIV
- Human immunodeficiency virus
- HLA
- Human leukocyte antigen
- HSPC
- Hydrogenated soy phosphatidylcholine
- ICH
- International Conference for Harmonization
- ICTAC
- International Confederation for Thermal Analysis and Calorimetry
- IMM
- Inner mitochondrial membrane
- IMS
- Intermembrane space
- IND
- Investigational new drug application
- ITF
- Innovation task force
- IUPAC
- International Union of Pure and Applied Chemistry
- KET
- Key enabling technologies
- LC
- Liquid crystal
- LFM
- Lateral force microscopy
- LTL
- Ligand‐targeted liposome
- LNP
- Lipid nanoparticle
- LUV
- Large unilamellar vesicle
- LVEM
- Low voltage electron microscopy
- MAA
- Marketing authorization application
- MAS 13C‐NMR
- Magic angle spinning 13C‐nuclear magnetic resonance
- MDM
- Material data mining
- MHM
- Modified heating method
- MPEG‐DSPE
- Methoxypolyethylene glycol‐distearoyl‐phosphatidylcholine
- MPEG 2000‐DSPE
- Methoxypolyethylene glycol 2000‐distearoyl‐phosphatidylcholine
- MPP
- Mitochondria penetrating peptide
- MPS
- Mononuclear phagocyte system
- MRI
- Magnetic resonance imaging
- MLV
- Multilamellar vesicle
- mtDNA
- mitochondrial DNA
- MVL
- Multivesicular liposome
- MVV
- Multivesicular vesicle
- MLL
- Multilamellar liposomes
- NASBA
- Nucleic acid sequence‐based amplification
- NBCD
- Non‐biological complex drugs
- NCI
- National Cancer Institute
- NDA
- New drug application
- NFAS
- Non‐flame atomic spectroscopy
- NHT
- New health technology
- NIR
- Near infrared
- NLC
- Nanostructured lipid carriers
- NMR
- Nuclear magnetic resonance
- NNI
- National nanotechnology initiative
- NP
- Nanoparticle
- NPLD
- Non‐PEGylated liposome doxorubicin
- OLV
- Oligolamellar vesicle
- OMM
- Outer mitochondrial membrane
- OTC
- Over the counter
- PAMAM
- Poly(amidoamine)
- PC
- Phosphatidylcholine
- PCR
- Polymerase chain reaction
- PCS
- Photon correlation spectroscopy
- PDI
- Polydispersity index
- PDT
- Photodynamic therapy
- PE
- Phosphatidylethanolamine
- PEO
- Polyethylene oxide
- PEO‐PMPS
- Poly(ethylene oxide)‐poly(methylphenylsilane)
- PET
- Positron emission tomography
- PEG
- Polyethylene glycol
- PEG‐DMG
- Polyethyleneglycol‐dimyristoyl glycerol
- PLGA
- Poly(lactic‐co‐glycolic acid)
- PNP
- Polymeric nanoparticles
- PPP
- Public–private partnership
- PPI
- Protein–protein interaction
- PRIME
- Priority medicines program
- QSAR/QSPR
- Quantitative structure–activity/property relationship
- RAS protein
- Rat sarcoma virus protein
- RBD
- Receptor binding domain
- REM
- Reflection electron microscopy
- RES
- Reticuloendothelial system
- ROS
- Reactive oxygen species
- RT‐PCR
- Reverse transcription polymerase chain reaction
- sCTMP
- Somatic cell therapy medicinal...
| Erscheint lt. Verlag | 22.7.2024 |
|---|---|
| Mitarbeit |
Herausgeber (Serie): Dennis Douroumis, Alfred Fahr, Juergen Siepmann, Martin J. Snowden, Vladimir P. Torchilin |
| Sprache | englisch |
| Themenwelt | Naturwissenschaften ► Chemie |
| ISBN-10 | 1-394-27407-6 / 1394274076 |
| ISBN-13 | 978-1-394-27407-9 / 9781394274079 |
| Haben Sie eine Frage zum Produkt? |
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