Integrative Omics in Parkinson's Disease

Joanne Trinh, Ph.D., is a Heisenberg professor at the Institute of Neurogenetics, University of Lübeck. Dr. Joanne Trinh received her doctorate in medical genetics at the University of British Columbia. She subsequently joined the Institute of Neurogenetics in Lübeck, where she obtained a faculty position. She is now head of the “Integrative Omics in Parkinson’s Disease” research group, which investigates the role of mosaic variants, nuclear and mitochondrial genome sequences, and lifestyle and environmental factors in parkinsonism. She is on the editorial board of Annals of Neurology and an associate editor of Frontiers in Neurology. Her research group in Lübeck will continue to use big-data approaches to elucidate the causes of neurological disease.

1. Introduction: evolution of omics
2. Monogenic and Complex genetics PD
3. Genetic risk scores
4. Mendelian Randomization
5. Methods to investigate somatic structural variants in synucleinopathies
6. Mitochondrial genetics
7. Epigenetics in PD genes
8. The microbiome
9. Genetic modifiers in reduced penetrance: X-linked dystonia
10. Long-read transcriptomics in neurodegeneration
11. Gene-environment interactions and behaviour
12. Introduction to prediction modeling using machine learning and omics data
13. IPSCs and OMICs merging