Integrative Omics in Parkinson's Disease

Dr. Joanne Trinh began her studies in the field of movement disorders while training for her BSc and PhD in medical genetics at the University of British Columbia. Following a scientific fellowship at the University of Antwerp, Belgium, Dr. Trinh returned to Canada to complete her work on genetic modifiers in LRRK2 parkinsonism. She subsequently joined the Institute of Neurogenetics in Lübeck, directed by Dr. Christine Klein, where she obtained a faculty position. She is now head of the “Integrative Omics in Parkinson’s disease” research group, which investigates the role of nuclear and mitochondrial genome sequences and lifestyle and environmental factors in parkinsonism. Her research group in Lübeck will continue to use big-data approaches to elucidate the causes of neurological disease.

1. Introduction: evolution of omics
2. Monogenic and Complex genetics PD
3. Genetic risk scores
4. Somatic mosaic variants
5. Structural variant detection
6. Mitochondrial genetics
7. Epigenetics in PD genes
8. Single-cell sequencing
9. The microbiome
10. Exposome biology in PD
11. Genetic modifiers in reduced penetrance: X-linked dystonia parkinsonism as a model
12. Long-read transcriptomics in neurodegeneration
13. Gene-environment interactions and behavior
14. Application of artificial Intelligence