Selected Topics in Mass Spectrometry in the Biomolecular Sciences

Part 1 Methods in mass spectrometry: electrospray ionization - theory and application, S.J. Gaskell; atmospheric-pressure ionization (ESI and APCI), A. Raffaelli; matrix-assisted laser desorption-ionization (MALDI) mass spectrometry - principles and applications, M. Karas and U. Bahr; high-sensitivity ESI and MALDI MS, T.B. Farmer and R.M. Caprioli; optimized GS/MS interfacing systems and operating conditions, P.J. Arpino; quantitative analysis by mass spectrometry - some important considerations, M.W. Duncan; optimization of mass-spectrometric ionization-efficiency data, I.T. Ozgen et al; role of internal energy in mass-spectrometric fragmentation, K. Vekey; interaction of metal ions and protons with simple biomolecules; structure information from bond energies and entropy effects, B.A. Cerda et al; a promising marriage between theory and experiment - density-functional method versus mass spectrometry, T. Marino et al. Part 2 Instrumentation for mass analysis and detection: recent advances in magnet-sector mass spectrometry, O.V. Menirovskiy et al; quadrupole mass filters and quadrupole ion traps, R.G. Cooks et al; time-of-flight mass spectrometry, M.L. Vestal; combined analyzer technologies, P. Kofel and U.P. Schlunegger; Fourier-transform mass spectrometry; M.L. Easterling and I.J. Amster. Part 3 Application to biomolecules: protein characterization by MS in pharmaceutical industry, D. Muller et al; folding pathways of disulphide containing proteins, M. Ruoppolo et al; integration of chemical modification reactions and mass-spectrometric methods in protein characterization, S. Foti; PSD-MALDI analysis of peptides, B. Spengler; development of a mass-spectrometric approach for the characterization of haemoglobin adducts, P. Ferrante et al; reactivity of antineoplastic drugs with model peptides studied by advanced mass-spectrometry methodologies, V. Carbone et al; applications of mass spectrometry in biochemical studies of nucleosides, nucleotides and nucleic acids, R.P. Newton; MALDI mass analysis of oligonucleotides, U. Bahr and M. Karas; DNA adducts in human carcinogenesis, H. Bartsch; MALDI MS of oligo and polysaccharides, D. Garozzo; mass spectrometry of isoeicosanoids as novel lipid substances, R.C. Murphy and R.J. Waugh; the role of mass spectrometry in the characterization of plant metabolites from crude extracts, A. De Nino et al; environmental applications of mass spectrometry - toxaphene analysis, F.I. Onuska and R.J. Maguire; the determination of polar compounds in the aquatic environment, M.J.F. Suter; some mass-spectrometry contributions in the study of cultural heritage, P. Agozzino.