Modern CNS Drug Discovery

Rudy Schreiber got his B.S. in Medicinal Biology and his Ph.D. in Neuropharmacology from the University of Groningen in the Netherlands. He started his career in central nervous system drug discovery in 1993. Subsequently he progressed from bench scientist to senior leadership roles at global pharmaceutical companies, including Servier (France), Bayer (Germany), Roche (CA) and Sepracor (currently, Sumitomo Pharma America, Inc, MA). From 2010 till 2012 he was the SVP of the Neurobiology group of the contract research organization, Evotec (Germany). Rudy's drug discovery experience covers a wide range of psychiatric and neurologic indications. He also worked with many different classes of molecular targets and led projects ranging from the idea stage throughout proof of principle testing. He has published more than 100papers and 30 patents. In 2012, he founded Suadeo Drug Discovery Consulting LLC in Boston. Rudy joined Maastricht University in 2018 and is coordinator of the 2-year research master program Drug Development and NeuroHealth. After this career change, he (re)discovered his interest for education, especially for training the next generation of drug hunters and neuro-entrepreneurs. Modern CNS Drug Discovery is a testament to this new found passion. Rudy is a Homo Aquaticus who lives on a boat in Maastricht Marina and spends his free time rowing on the Maas River or sailing offshore.

Part 1. Training the next generation of life science professionals.-Chapter 1. Preparing drug discovery scientists for a career in start-ups.-Chapter 2. Innovator, Entrepreneur, Leader: The Tripartite Drug, Discovery Neuroscientist.- Chapter 3. From Scientists to Innovators for Industry: an European program addressing the workforce challenge in the pharma industry.-Part 2. Recent developments in CNS drug discovery: from genes and molecules to animals.-Chapter 4. Drug Discovery in CNS: Finding a Target for What?.-Chapter 5. The Guardian of the Brain: Understanding the Blood-Brain Barrier and its Role in CNS Drug Discovery.-Chapter 6.Mass Spectrometry-Based Methods in CNS Drug Discovery.-Chapter 7. Neurogenomics with Application to Schizophrenia and Other Major Neuropsychiatric Diseases with Complex Heredity.-Chapter 8. Epigenetics in Drug Discovery: Achievements and Challenges.-Chapter 9.CNS biased agonism and the promise of targeting drugs beyond receptors to cellular pathways.-Chapter 10. Conventional Behavioral Models and Readouts in Drug Discovery: The Importance of Improving Translation.-Part 3. Translational Neuroscience and Technology.-Chapter 11. Connecting the dots in translational neuroscience.-Chapter 12. Safety and Drug Metabolism: Toward NCE and First in Human.-Chapter 13. Electrophysiology: From Molecule to Cognition, from Animal to Human.-Chapter 14. MRI in CNS Drug Development.-Chapter 15. Positron Emission Tomography in Drug Development.-Chapter 16. Application of Cognitive Test Outcomes for Clinical Drug Development.-Chapter 17. Exciting Research in the Field of Sexual Psychopharmacology: Treating Patients with Inside Information.-Part 4. Transdiagnostic Neurotherapeutics.-Chapter 18. Transformative CNS drug discovery.-Chapter 19.A Paradigm Shift from DSM-5 to Research Domain Criteria: Application to Translational CNS Drug Development.-Chapter 20.The exposome paradigm: applications in psychopathology and psychopharmacology.-Chapter 21. Medical devices for neurmodulation: A Comprehensive Overview of Different Methods of Non-invasive Brain Stimulation.-Chapter 22. Non-invasive Brain Stimulation: an evidence-based nonpharmacological treatment for Psychiatric and Neurological disorders.-Part 5. Clinical Development and regulatory approval.-Chapter 23.The Special Challenges of Developing CNS Drugs.-Chapter 24_Phase 1 Clinical Trials in Psychopharmacology.-Chapter 25. Early Development of Erenumab for Migraine Prophylaxis.-Chapter 26. Microdosing Psychedelics as a Promising New Pharmacotherapeutic.-Chapter 27.Partnering with the FDA.