Redox Signaling in Wound Healing in Elderly Populations: Theoretical Basis, Part 1

Richard Faragher is Professor of Biological Gerontology at the University of Brighton and is past Chair of the British Society for Research on Ageing, the International Association of Biomedical Gerontology and the American Aging Association. He read Biochemistry at Imperial College, London and undertook doctoral studies on human premature ageing at the University of Sussex. His primary research interest is the relationship between cellular senescence and organismal ageing. He has published widely on the phenotype of senescent cells and on compounds that reverse the process. He holds the Royal Pharmaceutical Society Conference Science Medal for his work on the mechanisms of Werner’s syndrome, the Help the Aged ‘Living Legend’ award for his championship of older people, the Paul F Glenn Award for research into the mechanisms of ageing and the British Society for Research on Ageing’s highest honour, the Lord Cohen of Birkenhead Medal. Professor Faragher is a Fellow of the American Aging Association and has served as a member of the Research Advisory Council of the Charity Research into Ageing and on strategy and funding panels for the BBSRC, the US National Institutes on Ageing and the European Union. From 2005-2008 he was Co-director of the BBSRC-EPSRC SPARC programme, a research network designed to build national capacity to conduct inter-disciplinary ageing research. He is currently a Director of the American Federation for Aging Research, serves on the Scientific Advisory Board of the Longevity Vision Fund and co-directs the BBSRC-MRC funded Building Links in Ageing Science and Translation (BLAST) research network. Ufuk Çakatay (May 09, 1965 –) is a Turkish biochemist and biogerontologist. He is a full professor of medical biochemistry at Istanbul-University Cerrahpasa in Istanbul, Turkey. He has a long-standing interest in oxidative protein damage, redox signaling, and biomarkers of proteostasis. Much less is known about the relationship between redox signaling events and senescent cells. However, it has been shown that the number of senescent cells in many tissues increases with age and that senescent cells are found in various age-related diseases. The development of experimental animal models for age-related disorders and the optimization of various bioanalytical techniques for the assessment of redox status in aging tissue are among his major research interests. Professor Çakatay has authored more than 100 publications in several leading journals, including research papers, book chapters, editorials, and invited reviews on free radical biology, aging, diabetes, redox signaling, and senotherapeutics. He has been a guest editor, reviewer, and editorial board member for more than 50 journals. In addition, Professor Çakatay has a keen interest in mentoring medical students and promoting their research careers. He has received several prestigious awards, including the Top Reviewer Award from Elsevier Science Publishing, and was a former member of the Animal Research and Ethics Committee of Istanbul University. Dr. Atayik is currently working in the Department of General Surgery at Hacettepe University Faculty of Medicine. He has been working as a scientist and researcher with Prof. Ufuk Çakatay since 2017. His research interests are in the fields of aging, age-related disorders, redox biology, oncogenetics, melatonin, mitochondria, surgical advances, and developing novel techniques for modern surgery. Dr. Atayik has conducted clinical research and experimental studies. He has published many scientific papers, such as research papers, narrative reviews, and book chapters, and has worked as an author, referee, editorial assistant, and guest editor, and editor in many prominent publishing houses. He was awarded the Young Investigator Presentation Prize at the VIII. International Congress of Molecular Medicine, which was held in Istanbul, Turkey, in November 2021.

1. Redox signaling in regenerative medicine: Regulatory mechanisms and therapeutic implications
Ali M. Sharifi, M. Amin Sharifi and Tunku Kamarul

2. Age-related aspects of redox signaling cascades of wound healing
Golden Kumari, Monalisha Padhiary and Arttatrana Pal

3. Wound healing in the elderly: Role of Nrf2 in combating oxidative stress
Tetiana R. Dmytriv, Oleh Lushchak and Volodymyr I. Lushchak

4. Impact of senescence in impaired wound healing
Gabriel Méndez-Valdés, Catalina Rojas-Solé, José Lillo-Moya and Ramón Rodrigo

5. Role of immunosenescence in impaired wound healing with age
Izzet Altintas, Ove Andersen and Jan O. Nehlin

6. Targeting redox signaling pathway through integration of caloric restriction and wound healing process for enhanced repair
Prachi Agarwal, Shweta Verma and Abhishek Kumar Singh

7. CoQ10, more than an antioxidant in skin health and wound healing promotion
Juan Diego-Hernandez-Camacho and Guillermo López Lluch