Tyrosinase

Dr. Claudiu T. Supuran received his BSc in chemistry from the Polytechnic University of Bucharest, Romania (1987) and PhD in chemistry at the same university in 1991. In 1990, he became Assistant and then Associate Professor of Chemistry at the University of Bucharest. He was Visiting Scholar at the University of Florida, Gainesville, United States, at Griffith University, Brisbane, Australia, and Visiting Professor at University of La Plata, Argentina. In 1995 he moved to the University of Florence, Italy, where he is currently Full Professor in the Department of Neuroscience, Psychology, Medicine and Child Health. His main research interests include design of enzyme inhibitors and activators, heterocyclic chemistry, chemistry of sulfonamides, sulfamates, and sulfamides, biologically active organo-element derivatives, QSAR studies, X-ray crystallography of metallo-enzymes, metal complexes with biologically active ligands (metal-based drugs), carbonic anhydrases, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives among others. He has published more than 1900 papers in these fields.

Preface
Claudiu T. Supuran
1. Overview on tyrosinases (genetics, molecular biology, phylogenetic relationship)
Clemente Capasso
2. Catalytic mechanism of tyrosinases
Ali Akbar Saboury and Samaneh Zolghadri
3. Structural Characterization of Tyrosinases and an Update on Human Enzymes
Luigi F. Di Costanzo
4. Natural products as tyrosinase inhibitors
Suleyman Akocak and Aslinur Dogan
5. Drug design of tyrosinase inhibitors
Simone Carradori, Francesco Melfi, Cristina Campestre, Arianna Granese and Amar Osmanovic
6. Peptide and peptidomimetic tyrosinase inhibitors
Paolo Rovero, Anna Maria Papini, Claudiu T. Supuran, Fosca Errante and Lucrezia Sforzi
7. Computational studies of tyrosinase inhibitors
Paola Gratteri and Alessandro Bonardi
8. Bacterial tyrosinases and their inhibitors
Ali Irfan
9. Biomedical applications of tyrosinases and tyrosinase inhibitors
Claudiu T. Supuran, Luigi Pisano and Martina Turco