Innovations and Advances in Wound Healing

Seung-Kyu Han, MD, PhD., is a professor in Plastic surgery at Korea University College of Medicine and a director of Diabetic Wound Center at Korea University Guro Hospital.

1. Basics of Wound Healing.- 1) Clinical Anatomy of the Skin.- 2) Wound Overview.- 3) Wound Healing Process.- 4) Conventional Wound Healing Methods.- 2. Interactive Wound Dressings.- 1) Overview.- 2) Classification.- 3) Polyurethane Foam Dressing.- 4) Bioelectric Dressing.- 5) Antimicrobial Dressing.- 6) Dressing Selection.- 3. Biologic Dermis Graft.- 1) Autogenous Dermis Graft.- 2) Allogenic Dermis Graft.- 3) Artificial Dermis Graft.- 4. Tissue-engineered Dermis Graft.- 1) Artificial Dermis vs Tissue-Engineered Dermis.- 2) Fibroblast-Seeded Artificial.-  Dermis.- 3) Adipose-Derived SVF Cell- Seeded Artificial Dermis.- 5. Usefulness of Fibrin Glue.- 1) Delivery Vehicle.- 2) Tissue Adhesive.- 3) Microsurgery.- 6. Unique Surgical Technique.- 1) Arterial Island Flap.- 2) Venous Island Flap.- 3) Staged Excision Technique to Reduce Scar Length.- 7. Management of Chronic Wounds - With Focus on Diabetic Ulcers.- 1) Why is Diabetic Ulcer Focused on?.- 2) Why does Diabetic Ulcer Get into Trouble?.- 3) Factors Contributing Delayed Healing.- 4) Risk Factors for Major Amputation.- 5) Management of Ischemia.- 6) Necessity of Collaboration.- 7) Developing Wound Dressing Team.- 8) Present and Future.- 8. Significance of Skin Hydration Level.- 1) Peripheral Neuropathy and Skin Hydration.- 2) Microangiopathy and Skin Hydration.- 3) Skin Hydration and Diabetic Wound Healing.- 9. Infection, Debridement, and Biofilm.- 1) Diagnosis.- 2) Microbiology of Diabetic Foot Infection.- 3) Treatment.- 4) Debridement.- 5) Biofilm.- 10. Negative-Pressure Wound Therapy (NPWT).- 1) Composition of NPWT Device.- 2) Mechanism of Action.- 3) Clinical Application.- 4) NPWT in Diabetic Foot Ulcers.- 11. Growth Factor Therapy.- 1) Overview.- 2) Background.- 3) Platelet-derived Growth Factor.- 4) Basic Fibroblast Growth Factor.- 5) Epidermal Growth Factor.- 12. Cell Therapy.- 1) Overview.- 2) Fibroblasts.- 3) Keratinocytes.- 4) Adipose-Derived SVF Cells.- 5) Platelet Concentrates.- 6) Mesenchymal StemCells.- 7) Adipose Derived Stem Cells.- 8) Limitations.- 13. Adipose Tissue and Its Derivatives.- 1) SVF Cells for Wound Coverage.- 2) SVF Cell Injection.- 3) Adipose Derived Stem Cells.- 4) Micronized Adipose Tissue Niche.- 14. Adjunctive Therapy.- 1) Nutritional Support.- 2) Electrical Stimulation.- 3) Ultrasound.- 4) Oxygen Therapy.- 5) Monochromatic Infrared Energy.- 6) Ultraviolet Light.- 7) Pain Scrambler Therapy.- 8) Foot Massager Device.- 9) Extracorporeal Shock Wave Therapy.- 15. Injectable Tissue-engineered Soft Tissue.- 1) Injectable Soft Tissue Using Fibroblasts suspended in Hyaluronic Acid Filler.- 2) Injectable Soft Tissue Using Fibroblasts.- 3) Injectable Soft Tissue Using Adipose-Derived Cells.