Proteomics for Drug Discovery

A Multiplexed Single Cell Proteomic Workflow Applicable to Drug Treatment Studies.- Systematic Identification of Kinase Substrates Relationship by Integrated Phosphoproteome and Interactome Analysis.- Quantitative Membrane Proteomics for Discovery of Actionable Drug Targets at the Surface of RAS Driven Human Cancer Cells.- Using Photoreactive Probes to Identify Viable Drug Targets in NonSmall Cell Lung Cancer.- A Microdissection Protocol for Proteogenomic Analysis of Histological Sections to Advance Drug Development.- Unbiased Quantitative Proteomics of Organoid Models of Pancreatic Cancer.- Drug Screening Using Normal Cell and Cancer Cell Mixture in an Automated 3D Cell Culture System.- Proteogenomic Workflow for Characterization of Microphthalmia Transcription Factor (MiT) Family Translocation Renal Cell Carcinoma.- A Tip Based Workflow for Sensitive IMAC Based Low Nanogram Level Phosphoproteomics.- Microfluidic Sample Preparation for Multiplexed Single Cell Proteomics Using a Nested Nanowell Chip.- 12 Plex Isobaric Multiplex Labeling Reagents for Carbonyl Containing Compound (SUGAR) Tag Enabled High Throughput Quantitative Glycomics.- Automated Immunoprecipitation Workflow for Comprehensive Acetylome Analysis.- A Fast Tracking Sample Preparation Protocol for Proteomics of Formalin Fixed Paraffin Embedded Tumor Tissues.- Identification of Proteomic Biomarkers of Acetaminophen Induced Hepatotoxicity Using Stable Isotope Labeling.- Reusing Peptide Spectral Reference Libraries to Discover Putative Plasma Biomarkers of Response to Cancer Chemotherapy.- Targeted Mass Spectrometry for Quantification of Receptor Tyrosine Kinase Signaling.- Detection and Quantitation of Endogenous Membrane-Bound RAS Proteins and KRAS Mutants in Cancer Cell Lines Using 1D SDS PAGE LC-MS2.- Determining KRAS4B Targeting Compound Specificity by Top Down Mass Spectrometry.