Research in Chronic Viral Hepatitis

I. Replication of hepatitis viruses.- In vitro culture systems for hepatitis B and delta viruses.- Chronic infection in wood-chucks infected by a cloned hepatitis delta virus.- Detection of replicative intermediates of viral RNA in peripheral blood mononuclear cells from chronic hepatitis C virus carriers.- Susceptibility of human liver cell cultures to hepatitis C virus infection.- II. Molecular biology of hepatitis B virus.- Molecular basis of the diversity of hepatitis B virus core-gene products.- Characterization of the endogenous protein kinase activity of the hepatitis B virus.- The hepatitis B virus X gene product transactivates the HIV-LTR in vivo.- Accumulation of a cellular protein bearing c-myc-like antigenicity in hepatic and non-hepatic delta antigen expressing cells.- Duck hepatitis B virus infection, aflatoxin B1 and liver cancer in ducks.- III. Pathogenic and protective immune responses against hepatitis viruses.- Cell mediated immune response to hepatitis B virus nucleocapsid antigen.- Clinical and immunological aspects of hepatitis B virus infection in children receiving multidrug cancer chemotherapy.- Hepatitis C virus infection in type II essential mixed cryoglobulinemias.- Detection of hepatitis B virus DNA by polymerase chain reaction in vaccinated and non-vaccinated Senegalese children.- Duck hepatitis B virus (DHBV) as a model for understanding hepadnavirus neutralization.- IV. Variability of hepatitis B virus.- Implication of genetic variation on the pathogenesis of hepatitis B virus infection.- Hepatitis B virus C-gene variants.- Long-term response to interferon therapy in chronic hepatitis B: importance of hepatitis B virus heterogeneity.- Significance and relevance of serum preS1 antigen detection in wild-type and variant hepatitis B virus (HBV) infections.- Complete nucleotide sequences of six hepatitis B viral genomes encoding the surface antigen subtypes ayw4, adw4q?, and adrq? and their phylogenetic classification.- V. Diagnosis of chronic viral hepatitis.- Role of IgM antibody to hepatitis B core antigen in the diagnosis of hepatitis B exacerbations.- Serum IgM antibodies to hepatitis C virus in acute and chronic hepatitis C.- Isolate antibody to hepatitis C virus core antigen (C22) by RIB A 2: correlation with HCV-RNA and anti-NS5.- Is HCV transmitted by the vertical/perinatal route?.- VI. Clinical course and therapy of chronic viral hepatitis.- Multiple viral infections in HIV-infected children with chronically-evolving hepatitis.- Lymphoblastoid interferon in chronic hepatitis C patients that were "non responders" to recombinant interferon alpha (rIFN alpha).- Non responders to interferon therapy among chronic hepatitis patients infected with hepatitis C virus.- The relationship between LeY antigen and the therapeutic efficacy of interferon in chronic hepatitis C.- Antibodies to interferon alpha in patients.- VII. Liver transplantation and chronic viral hepatitis.- Patterns and mechanisms of hepatitis B/hepatitis D reinfection after liver transplantation.- Hepatitis C virus infection in liver allograft recipients.