Proteins

Jia-huai Wang is Associate professor at the Dana-Farber Cancer Institute, Harvard Medical School, USA. As a veteran structural biologist specialized in cell surface receptors functioning in immune system and nervous system he has around 140 peer-reviewed papers published, including 11 articles in Nature, Science and Cell. When in China, in the early 1970’s, he was the team member which determined the structure of insulin, one of the world’s first dozen protein structures solved. Since 1988 he has been working at Harvard. As a leading author, he has published a series of extremely important structures, such as the first virus structure CD4, the first cell adhesion interacting complex CD2/CD58, the ground-breaking preTCR-ligand interacting complex and the prototypical axon guidance cue netrin-1 interactions. He has a deep understanding about protein structure and how a protein functions.

1. From “What is wave” to “What is life” to the booming structural biology 2. From a to b: The beginning of protein structure analyses 3. Proteins-in-modules and genes-in-pieces. How proteins evolve 4. How one structure has changed a field—the MHC molecules in cellular immunity 5. T cell receptors, the molecular bodyguard in ab T lymphocyte immunity 6. Protein-mediated cell-cell interactions in multicellular biology 7. How do viruses assemble and infect their host cells? 8. AlphaFold2, the successful prediction of three-dimensional protein structures and its impact on structural biology