Recent Advances in Cell Biology of Acute Leukemia

An overview of the cell-biological features of acute leukaemias. Based on survey articles and clinical multicentre studies in children and adults with ALL or AML, the book details the significance of immunologic, cytogenic and molecular-biologic analysis in the classification of acute leukemia.

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This volume gives an overview of the state of the art regarding cell-biological features of acute leukemias. Based on survey articles and results of clinical multicenter studies in children and adults with ALL or AML, it offers a detailed presentation concerning the significance of immunologic, cytogenic and molecular-biologic analyses in the classification of acute leukemia and the identification of clinical risk groups. Current immunological and molecular-biological techniques for detecting minimal residual disease are described and their possibilities and limitations discussed. Further main topics include preclinical investigations and first clinical experience with interleukin 2-based immunotherapy in acute leukemia, biological features of new hematopoietic growth factors and recent advances in the molecular understanding of the genetic defects in leukemic cells.