Charney and Nestler's Neurobiology of Mental Illness

Dennis S. Charney, MD Anne and Joel Ehrenkranz, Dean, Icahn School of Medicine at Mount Sinai President for Academic Affairs Mount Sinai Health System Professor, Departments of Psychiatry, Neuroscience, and Pharmacological Sciences New York, NY USA Eric J. Nestler, MD, PhD Nash Family Professor of Neuroscience Director, Friedman Brain Institute Dean for Academic Affairs Icahn School of Medicine at Mount Sinai Chief Scientific Officer of the Mount Sinai Health System New York, NY USA Joseph D. Buxbaum, PhD G. Harold and Leila Y. Mathers Professor, Departments of Psychiatry, Neuroscience, and Genetics and Genomic Sciences Deputy Chair, Department of Psychiatry Director, Seaver Autism Center for Research and Treatment Icahn School of Medicine at Mount Sinai New York, NY USA Elisabeth B. Binder. MD Director, Department of Genes and Environment Max Planck Institute of Psychiatry Munich, Germany Joshua A. Gordon, MD Director, National Institute of Mental Health Bethesda, MD USA Marina R. Picciotto Charles B. G. Murphy Professor of Psychiatry and Professor Child Study Center, of Neuroscience and of Pharmacology Director, Division of Molecular Psychiatry Deputy Chair for Basic Science Research, Dept. of Psychiatry Deputy Director, Kavli Institute for Neuroscience Co-Director, Neuroscience Research Training Program Yale Department of Psychiatry New Haven, CT USA

SECTION 1: EMERGING AND ESTABLISHED TECHNOLOGIES
Section Editors: Eric J. Nestler and Kafui Dzirasa

1. Genetic Methodologies and Applications
Ben Neale

2. Multiscale Network Approaches to Decode the Complexity
of Common Human Diseases
Minghui Wang, Yiyuan Liu, Eric Schadt, and Bin Zhang

3. The Role of the Epigenome in Brain Development, Function, and Disease
Schahram Akbarian, John F. Fullard, Kiran Girdhar, and Panos Roussos

4. Methods for In Vivo Gene Manipulation
Lisa M. Monteggia and Wei Xu

5. Application of Stem Cells to Understanding
Psychiatric Disorders
Marcella, Burtele, Giorgia Quadrato, and Kristen Brennand

6. Optogenetics and Related Technologies for Psychiatric Disease Research: Current Status and Challenges
Lief E. Fenno and Karl Deisseroth

7. Methods for In Vivo Circuit Analysis
Micah Johnson, Yassine Filali, Radha Velamuri, Kafui Dzirasa, and Rainbo Hultman

8. Magnetic Resonance Methodologies
Hanzhang Lu and Peter A. Bandettini

9. PET Brain Imaging Methodologies
Ansel Hillmer, Kelly P. Cosgrove, and Richard E. Carson

10. Neuromodulation and Psychiatric Disorders
Andrew Smith, Martijn Figee, and Helen Mayberg


SECTION 2: SCHIZOPHRENIA
Section Editors: Judy Ford and Dan Mathalon

11. Diagnosis and Epidemiology of Schizophrenia
Julie Walsh-Messinger, Ariella Farzan Nikou, and Dolores Malaspina

12. Genetics of Schizophrenia
Sophie E. Legge, Antonio F. Pardiñas, and Michael C. O'Donovan

13. Neuroimaging and Circuit Mechanisms of Schizophrenia
Neil D. Woodward, Stephan Heckers, Dost Ongur, and Julia M. Sheffield

14. Animal and Cellular Models for the Study of Schizophrenia
Joshua A. Gordon

15. Neural and Circuit Mechanisms of Schizophrenia
Samuel J. Dienel and David A. Lewis

16. Glial-Immune Mechanisms of Schizophrenia: Animal and Human Studies
Kowsar Teymouri, Mahbod Ebrahimi, Jennie G. Pouget, and James L. Kennedy

17. Translational Models for Psychotic Symptoms
Phil Corlett

18. Current Treatments for Schizophrenia
Donald C. Goff

19. Novel Approaches for Treating Schizophrenia
Steve M. Paul and Alan Breier


SECTION 3: BIPOLAR DISORDER
Section Editor: Alex Charney

20. Diagnosis and Epidemiology of Bipolar Disorder
Kathleen R. Merikangas and Emma K. Stapp

21. Genetics of Bipolar Disorder
Dongjing Liu and Niamh Mullins

22. Neuroimaging and Circuit Mechanisms of Bipolar Disorder
E. Kale Edmiston, Michele A. Bertocci, Merage Ghane-Ezabadi, and Mary L. Phillips

23. Animal and Cellular Models for the Study of Bipolar Disorder
Michael J. McCarthy and Jared W. Young

24. Molecular and Cellular Mechanisms of Bipolar Disorder: Animal and Human Studies
Colleen A. McClung and Hilary P. Blumberg

25. Current Treatments for Bipolar Disorder
Nicole W. Simons and Alexander W. Charney

26. Novel Approaches for Treating Bipolar Disorder
Nefize Yalin, Allan H. Young, and Carlos A. Zarate, Jr.


SECTION 4: DEPRESSION
Section Editor: John Krystal

27. Diagnosis and Epidemiology of Depression
James W. Murrough

28. Genetics of Depression
Daniel Levey and Joel Gelernter

29. Neuroimaging and Circuit Mechanisms of Depression
Adrienne L. Romer, Michele A. Bertocci, Mary L. Phillips, and Diego A. Pizzagalli

30. Animal Models for the Study of Depression
Lyonna F. Parise, Astrid M. Cardona-Acosta, Eric M. Parise, and Carlos A. Bolaños-Guzmán

31. Neurotrophic Mechanisms of Depression: Animal and Human Studies
Lisa M. Monteggia

32. Glial-Immune Mechanisms of Depression: Animal and Human Studies
Georgia E. Hodes, Caroline Ménard, Madeline L. Pfau, and Scott J. Russo

33. Neuroendocrine Mechanisms of Depression: Animal and Human Studies
Elisabeth B. Binder and Jan M. Deussing

34. Current Treatments for Depression
Maurizio Fava and John Krystal

35. Novel Approaches for Treating Depression
Eric J. Nestler, Dennis S. Charney, John H. Krystal, and James W. Murrough


SECTION 5: ANXIETY AND TRAUMA-RELATED DISORDERS
Section Editor: Kerry J. Ressler

36. Diagnosis and Epidemiology of Anxiety, Obsessive-Compulsive, and Trauma- and Other Stress-Related Disorders
Murray B. Stein, Meghan E. Keough, and Peter P. Roy-Byrne

37. Genetics of Anxiety and Trauma-Related Disorders
Sarah E. Benstock and John M. Hettema

38. Neuroimaging and Circuit Mechanisms of Anxiety and Trauma-Related Disorders
Gregory A. Fonzo

39. Animal Models for the Study of Anxiety Disorders
Caroline Jia, Hao Li, and Kay Tye

40. Biological Mechanisms of Anxiety Disorders: Animal and Human Studies
Danielle M. Gerhard, Anfei Li, Francis S. Lee, and Heidi C. Meyer

41. Biological Mechanisms of Stress Resilience: Animal and Human Studies
Saren H. Seeley, Sarah Boukezzi, Jonathan DePierro, Dennis S. Charney, and Adriana Feder

42. Current Treatments for Anxiety and Trauma-Related Disorders
Kristin L. Szuhany, Benjamin Feldman, Matteo Malgaroli, and Naomi M. Simon

43. Novel Approaches for Treating Anxiety and Trauma-Related Disorders
Alfred P. Kaye, Sarah Jefferson, and John H. Krystal


SECTION 6: SUBSTANCE USE DISORDERS
Section Editors: Nora Volkow and Yavin Shaham

44. Epidemiology of Substance Use Disorders
Denise B. Kandel, Pamela C. Griesler, Mei-Chen Hu, Philippe A. Melas, Bradley T. Kerridge, and Bridget F. Grant

45. Genetics of Substance Use Disorders
David Goldman and Danielle Sambo

46. Neuroimaging and Circuit Mechanisms of Substance Use Disorders
Edythe D. London, Chelsea L. Robertson, and Terry J. Prins

47. Animal Models for the Study of Substance Use Disorders
Christopher J. Evans, J. David Jentsch, Brigitte L. Kieffer, Rafael J. Maldonado, and Catherine M. Cahill

48. Cellular and Molecular Mechanisms of Substance Use Disorders: Animal and Human Studies
Kathryn J. Reissner

49. Brain Development and the Risk for Substance Use Disorders
Sonia G. Ruiz, B.J. Casey, and Arielle Baskin-Sommers

50. Current Treatments for Substance Use Disorders
Adam D'Sa, Andrew L. Gaddis, and Eric C. Strain

51. Novel Approaches for Treating Substance Use Disorders
Matthew L. Banks


SECTION 7: DEMENTIA
Section Editor: Alison M. Goate

52. Diagnosis and Epidemiology of Dementia
William C. Kreisl and Christiane Reitz

53. Genetics of Alzheimer's Disease, Parkinson's Disease, and Lewy Body Dementia
Alan E. Renton, Brian Fulton-Howard, Shea J. Andrews, Edoardo Marcora, and Alison M. Goate

54. Neuroimaging and Fluid Biomarkers of Alzheimer's Disease
Brian A. Gordon and Suzanne Schindler

55. Molecular and Cellular Mechanisms of Alzheimer's Disease: Animal and Human Studies
Gareth R. Howell and Gregory W. Carter

56. Molecular and Cellular Mechanisms of Primary Tauopathies: Animal and Human Studies
Shiaoching Gong and Li Gan

57. Neurobiology of Lewy Body Dementias: Animal and Human Studies
James E. Galvin and Jose Tomas Bras

58. Current Treatments for Alzheimer's Disease and Other Dementias
Mary Sano and Judith Neugroschil

59. Novel Approaches for Treating Alzheimer's Disease and Other Dementias
M. Catarina Silva, David C. Butler, Sally Temple, and Steve J. Haggarty


SECTION 8: PEDIATRIC PSYCHIATRIC DISORDERS
Section Editor: Joseph D. Buxbaum

60. Diagnosis and Epidemiology of Pediatric Psychiatric Disorders
Magdalena Janecka, Artemis Briasouli, Vahe Khachadourian, and Abraham Reichenberg

61. Genetics of Pediatric-Onset Psychiatric Disorders
Tess Levy and Joseph D. Buxbaum

62. Neuroimaging in Pediatric Psychiatric Disorders
Timothy P.L. Roberts and Luke Bloy

63. Neurobiology of Autism Spectrum Disorders and Intellectual Disability: Animal and Human Studies
Alexandra Massa, Jesse Costales, Silvia De Rubeis, Jennifer Foss-Feig, Patrick R, Hof, and Alexander Kolevzon

64. Neurobiology of Attention Deficit Hyperactivity Disorder: Animal and Human Studies
Tess Levy and Joseph D. Buxbaum

65. Neurobiology of Tic Disorders and Obsessive-Compulsive Disorder: Animal and Human Studies
Christopher Pittenger

66. Neurobiology of Eating Disorders: Animal and Human Studies
Thomas Hildebrandt and Annabel Susanin

67. Current Treatments for Pediatric Psychiatric Disorders
Paige M. Siper, M. Pilar Trelles, Yael Kufert, and Dorothy E. Grice

68. Novel Approaches for Treating Pediatric Psychiatric Disorders
Niki P. Sabetfakhri and Edwin H. Cook, Jr.


SECTION 9: FUTURE DIRECTIONS OF PSYCHIATRY
Section Editor: Dennis S. Charney

69. The Present and Future of Psychiatric Diagnoses
Steven E. Hyman

70. The NIMH Research Domain Criteria Project: Toward Precision Medicine in Psychiatry
Bruce N. Cuthbert

71. Computational Psychiatry and the Bayesian Brain
Karl J. Friston and Xiaosi Gu

72. Digital Assessments of Psychiatric Disorders
Rachel E. Quist, Sukanya Bhattacharya, Sarah M. Chacko, and Nicholas C. Jacobson

73. Digital Therapies of Psychiatric Disorders: Focus on Depression Symptoms
Bruno Biagianti, Mor Nahum, Neta Yitzhak, and Sofia Vinogradov

74. Psychedelic Drugs as Treatment Agents
Rachel Yehuda, Lauren A. Lepow, Philip A. Bonnano, Tamar Glatman Zaretsky, Josimar Hernandez Antonio, and Kathleen M. Jagodnik

75. Psychiatry's Past Challenges and Future Opportunities
Ryan E. Lawrence and Jeffrey A. Lieberman