Therapeutic Applications of Dopamine D3 Receptor Function -

Therapeutic Applications of Dopamine D3 Receptor Function

New Insight After 30 Years Of Research
Buch | Softcover
VIII, 275 Seiten
2024 | 1st ed. 2023
Springer International Publishing (Verlag)
978-3-031-23060-8 (ISBN)
160,49 inkl. MwSt
The CTBN volume Therapeutic Applications of Dopamine D3 Receptor Function reviews the state of the knowledge on the dopamine D3 receptor and its role in human behavior and disease (i.e.: neuropsychiatric illnesses including schizophrenia, mood disorders, Parkinson’s disease, restless legs syndrome, addictions and substance use disorders).
The CTBN volume Therapeutic Applications of Dopamine D3 Receptor Function reviews the state of the knowledge on the dopamine D3 receptor and its role in human behavior and disease (i.e.: neuropsychiatric illnesses including schizophrenia, mood disorders, Parkinson's disease, restless legs syndrome, addictions and substance use disorders). The volume is written by leading experts across multidisciplinary areas (imaging, biobehavioral testing and clinical trials, preclinical models / molecular pharmacology) converging on the therapeutic implications / potential of the D3 receptor.

The D3 dopamine receptor is a member of the D2-like family of G protein-coupled receptors. It was cloned and characterized almost 25 years ago. A key feature of the D3 dopamine receptor system, which has attracted considerable attention, is its anatomical localization remarkably restricted to the limbic circuitry. This has spurred the hypothesis that D3 involvement could contribute to the pathophysiology of neuropsychiatric disorders (or to some features of neuropsychiatric disorders), including but not limited to psychosis, addictions and substance abuse, mood and movement disorders.

Preface.- A Historic Review of the D3 Dopamine System from D3 Cloning to Clinical Trials in Schizophrenia and Drug Addiction.- Location, Location, Location: The Expression of D3 Dopamine Receptors in the Nervous System.- Recent Advances in Dopamine D3 Receptor Heterodimers: Focus on Dopamine D3 and D1 Receptor-Receptor Interaction and Striatal Function.- Involvement of DA D3 Receptor and Mitochondrial Functions in Structural Neuroplasticity of the Emotional Brain Circuits: Possible Role in Depression.- Dopamine D3 Receptor in Parkinson Disease: A Prognosis Biomarker and an Intervention Target.- Dopamine D3 Receptors: A Potential Target to Treat Motivational Deficits in Parkinson's Disease.- Therapeutic Challenges of Cognitive Dysfunctions in Neuropsychiatric Disorders: Focus on the Dopamine D3 Receptor.- Dopamine D3 Receptor in Stimulant and Opiate Use Disorders.- The Role of D3 Dopamine-Receptors in Nicotine Dependence:  A Synthesis of the Pre-Clinical and ClinicalLiterature.- The Dopamine D3 receptor in Food Addiction.- The Dopamine D3 Receptor Pharmacology and the Therapeutic Use of D3 Receptor Ligands in Schizophrenia.- D3 receptors and Restless Legs Syndrome.- D3 receptors and PET imaging.

Erscheinungsdatum
Reihe/Serie Current Topics in Behavioral Neurosciences
Zusatzinfo VIII, 275 p. 1 illus.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Gewicht 434 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Medizinische Fachgebiete Psychiatrie / Psychotherapie
Medizin / Pharmazie Pharmazie
Naturwissenschaften Biologie Humanbiologie
Naturwissenschaften Biologie Zoologie
Schlagworte D3 Receptor Agonists • D3 Receptor Antagonists • Depression • Dopamine D3 Receptors • Mesencephalon • Motivation • Neuropharmacology • Neuroplasticity • neuropsychiatric disorders • Obesity • Parkinson's Disease • Psychosis • Restless Legs Syndrome Cognition • Striatum • Substance use disorders
ISBN-10 3-031-23060-4 / 3031230604
ISBN-13 978-3-031-23060-8 / 9783031230608
Zustand Neuware
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