Textbook of Neural Repair and Rehabilitation: Volume 1, Neural Repair and Plasticity

Michael Selzer is Professor of Neurology at the University of Pennsylvania and Research Director in the Department of Physical Medicine Rehabilitation. He is editor-in-chief of Neurorehabilitation and Neural Repair, the official Journal of the American Society of Neurorehabilitation and the World Federation of Neurorehabilitation. Stephanie Clarke is Professor and Head of Neuropsychology at the University Hospital, Lausanne and President of the Swiss Society of Neurorehabiltation. Leonardo Cohen is Chief of the Human Cortical Physiology Section and Chief of the Stroke Rehabilitation Clinic at NINDS, Bethesda. Pamela Duncan is Professor of Health Services Administration and Physical Therapy, and Director of the University of Florida Brooks Center for Rehabilitation Studies, University of Florida. Fred Gage is Professor in the Laboratory of Genetics at the Salk Institute, and served as President of the Society for Neuroscience, 2001-2. He is a fellow of the American Association for the Advancement of Science and a member of the National Academy of Sciences and the Institute of Medicine

Preface; Neural repair and rehabilitation: an introduction; Part A. Neural plasticity: Part A1. Cellular and molecular mechanisms of neural plasticity: 1 Anatomical and biochemical plasticity of neurons: regenerative growth of axons, sprouting, pruning, and denervation; supersensitivity; 2 Learning and memory: basic principles and model systems; 3 Short-term plasticity: facilitation and post-tetanic potentiation; 4 Long-term potentiation and long-term depression; 5 Cellular and molecular mechanisms of associative and nonassociative learning; Part A2. Functional Plasticity in CNS System: 6 Plasticity of mature and developing somatosensory systems; 7 Activity-dependent plasticity in the intact spinal cord; 8 Plasticity of cerebral motor functions: implications for repair and rehabilitation; 9 Plasticity in visual connections: retinal ganglion cell axonal development and regeneration; 10 Plasticity in auditory functions; 11 Cross-modal plasticity in sensory systems; 12 Attentional modulation of cortical plasticity; Section A3. Plasticity after injury to the CNS; 13 Plasticity in the injured spinal cord; 14 Plasticity after brain lesions; 15 From bench to bedside: influence of theories of plasticity on human neurorehabilitation; Part B. Neural Repair: Part B1. Basic Cellular and Molecular Processes: 16 Neuronal death and rescue: neurotrophic factors and anti-apoptotic mechanisms; 17 Axon degeneration and rescue; 18 Adult neurogenesis and neural precursors, progenitors, and stem cells in the adult CNS; 19 Axon guidance during development and regeneration; 20 Synaptogenesis; Part B2. Determinants of Regeneration in the Injured Nervous System: 21 Inhibitors of axonal regeneration; 22 Effects of the glial scar and extracellular matrix molecules on axon regeneration; 23 Trophic factors and their influence on regeneration; 24 Intraneuronal determinants of regeneration; Part B3. Promotion of Regeneration in the Injured Nervous System: 25 Cell replacement in spinal cord injury; 26 Dysfunction and recovery in demyelinated and dysmyelinated axons; 27 Role of Schwann cells in peripheral nerve regeneration; 28 Transplantation of Schwann cells and olfactory ensheathing cells to promote regeneration in the CNS; 29 Trophic factor delivery by gene; 30 Assessment of sensorimotor function after spinal cord injury and repair; Part B4. Translational Research: Application to Human Neural Injury: 31 Alzheimer's disease, model systems and experimental therapeutics; 32 Biomimetic design of neural prostheses; 33 Brain-computer interfaces for communication and control; 34 Status of neural repair clinical trials in brain diseases; Index.