Principles of Medicinal Chemistry

Introduction and history; medicinals of plant origin - historical aspects; biopharmaceutical properties of drug substances; structural features and pharmacologic activity; theoretic aspects of drug design; molecular modelling; receptors and drug action; drug metabolism; volatile anaesthetics; central nervous system depressants - sedative-hypnotics; anticonvulsant; neuroleptics and anxiolytic agents; drugs used to treat neuromuscular disorders - antiparkinsonism agents and skeletal muscle relaxants; analgesics; central nervous system stimulants; local anaesthetics; cholinergic agonists, acetylcholinesterase inhibitors, and cholinergic antagonists; adrenergic drugs; cardiac agents - cardiac glycosides, antianginals and antiarrhythmic drugs; anticoagulants, coagulants and plasma extenders; diuretics; antiallergic and antiulcer drugs; cholesterol, adrenocorticoids, and sex hormones; antilipidemic drugs; nonsteroidal anti-inflammatory drugs; drugs affecting sugar metabolism; amino acids, peptides and proteins; pharmaceutical biotechnology; vitamins and coenzymes; thyroid function and thyroid drugs; metabolite antagonism; parasite chemotherapy; antimycobacterial agents; antibiotics and antimicrobial agents; antifungal agents; antiseptics and disinfectants; cancer chemotherapy; antiviral agents; approaches to anti-AIDS agents; hormone antagonists; photochemotherapy; pesticides; agents for organ imaging; appendix.