Human Developmental Neurotoxicology

David C. Bellinger

Introduction. Lead. Alcohol. EMERGING STORIES: OUTSTANDING ISSUES AND DATA NEEDS. PART A: ENVIRONMENTAL CHEMICALS. Methylmercury. Polychlorinated Biphenyls. Solvents. Pesticides. PART B: MEDICINALS. Retinoids.. Chemotherapeutic Drugs. PART C: RECREATIONAL SUBSTANCE USE. Maternal Smoking During Pregnancy and ETS. Cocaine. IMPROVING THE ASSESSMENT OF THE RELATIONSHIPS BETWEEN EXPOSURE AND CLINICAL DISEASE: DATA AND METHODS NEEDS. PART 1: EXPOSURE ASSESSMENT AND PHARMACOKINETIC MODELS. . Metals. Pesticides. Drugs of Abuse.. PART 2: ENDPOINT ASSESSMENT. Parallels Between Animal and Human Models of Nerobehavioral Disorders: General Considerations. Neuropsycchological Assessment Issues and Strategies. Role of Neuroimaging. Childhood Exposures and Adult Disease. PART 3: DATA ANALYSIS AND DEFINING BASES OF INDIVIDUAL SUSEPTIBILITY.. The Experimentalist Perspective. Applications of Structural Equation Modeling.. The Social-Ecological Perspective. Molecular Mechanisms.. PART 4: INCREASING THE RELEVANCE AND UTILITY OF DATA FROM DEVELOPMENTAL NEUROTOXICITY STUDIES TO CLINICAL PRACTICE AND TO RISK ASSESSMENT. Ethical Considerations. The Political and Economic Contexts.. Clinician Perspective. Public Health Perspective.