Cholinergic Involvement in Neurodegenerative Diseases

A. Claudio Cuello works in the Department of Pharmacology and Therupeutics at McGill University. Montreal, Quebec, Canada.

1. The history of the CNS cholinergic transmission
2. Organization of the basal forebrain cholinergic system in the human brain
3. The cholinergic synapses
4. Nicotinic acetylcholine receptors in the brain
5. Cognition and modulation of the cholinergic system
6. The involvement cholinergic system in Alzheimer disease
7. Structural changes to the basal forebrain cholinergic system in the continuum of the Alzheimer’s pathology
8. The NGF dependence of the basal forebrain cholinergic system
9. NGF based cholinergic therapies in Alzheimer disease
10. Memory network and cognitive reserve are associated with preserved and stimulated cholinergic neurotransmission
11. Cholinergic therapy in Alzheimer’s disease
12. CNS muscarinic receptors agonists in Alzheimer’s disease treatment
13. The Cholinergic system in down syndrome
14. The Cholinergic system in Parkinson disease
15. The Cholinergic system in dementia with lewy bodies
16. Epilogue. Future research avenues on the cholinergic involvement in neurodegenerative diseases