Hematopoietic Stem Cell Transplantation for Neurologic Diseases

Matilde Inglese is at the University Hospital IRCCS Ospedale Policlinico San Martino Department of Neurology, Genoa, Italy. Giovanni L. Mancardi is at the Universita di Genova, DINOGMI, in Genova, Italy.

1. Introduction to HSCT for neurologic diseases
2. Modification of T and B cell-associated immuno-pathological mechanisms in multiple sclerosis by disease modifying therapies: achievements and opportunities
3. The hematopoietic niche and the autoreactive memory in autoimmune disorders
4. The preclinical data and immunological rationale for hematopoietic stem cell transplantation in autoimmunity
5. Immune cell reconstitution following autologous hematopoietic stem cell transplantation in multiple sclerosis
6. Immune reconstitution in rheumatic disease patients after autologous hematopoietic stem cell transplantation
7. The role of chemotherapy in hematopoietic stem cell transplantation HSCT for autoimmune disorders: from lymphoablative to myeloablative conditioning protocols
8. The HSCT procedure (I): mobilization, collection, manipulation and cryopreservation of HSC
9. The HSCT procedure (II): conditioning, hemopoietic stem cell infusion, supportive care and monitoring
10. Early and late complications of HSCT
11. Hematopoietic Stem Cell Transplantation for Multiple Sclerosis
12. Hematopoietic stem cell transplantation for neuromyelitis optica spectrum disorder. Can immune tolerance be re-established?
13. Hematopoietic stem cell transplantation (HSCT) for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): Is it CIDP?
14. HSCT for Stiff Person Syndrome and Myasthenia Gravis
15. Autologous hematopoietic stem cell transplantation for pediatric autoimmune neurologic disorders
16. HSCT for systemic autoimmune diseases with neurologic involvement
17. Hematopoetic Stem Cell Therapy and Ex Vivo Gene Therapy for X-linked Adrenoleukodystrophy
18. Economics of Hematopoietic Stem Cell Transplant in immune-mediated neurologic autoimmune diseases
19. The EBMT-ADWP and the CIBMTR
20. Ongoing randomized clinical trials on HSCT in multiple sclerosis