Integrated Structural Biology

Angela Gronenborn is the head of the Department of Structural Biology at the University of Pittsburgh School of Medicine and the holder of the UPMC Rosalind Franklin Chair. She specializes in the use of NMR spectroscopy to study proteins and macromolecular complexes. Her work has focused on the study of proteins involved in human immunodeficiency virus (HIV) replication and she directs the Pittsburgh Center for HIV Protein Interactions. Tatyana Polenova is a Professor of Chemistry and Biochemistry and the Director of an NIH Center of Biomedical Research Excellence (NIH-COBRE, "Molecular Design of Advanced Biomaterials"). Her research focuses on understanding structure, dynamics and function of biomolecular assemblies, using magnetic resonance and computational methods. She studies physiologically important microtubule/cargo protein assemblies whose malfunction is associated with multiple diseases, HIV-1 capsid protein assemblies whose function is important in virus pathogenicity and biotechnologically important vanadium haloperoxidases. Her research involves development of new NMR techniques. Caitlin Quinn is an NMR Spectroscopist with the University of Delaware Nuclear Magnetic Resonance Core Facility. Her research focuses on applications of solid-state NMR to a wide range of biological, inorganic, and organic systems, with a particular interest in structure and dynamics of proteins associated with HIV-1 viral maturation and interactions with host factors. She is also interested in NMR methods development.

Decoding Atomic Addresses: Solution NMR Resonance Assignment of Proteins;Solid-state NMR Spectroscopy and Dynamic Nuclear Polarization;Electron Paramagnetic Resonance in Structural Biology;Cryo-electron Microscopy and Tomography: Going for Atomic Resolution in Macromolecular Assemblies and Entire Cells;In-cell Structural Biology Through the Integration of Solution NMR Spectroscopy and Computational Science;Solid-state NMR Based Integrative Structural Methods for Protein and Viral Assemblies;Time-resolved Crystallography on Protein Photoreceptors and Enzymes;Integrative Structural Biology of Enzyme Active Sites;Mechanistic Studies of Membrane Proteins Using Integrated Solid-state NMR and Computational Approaches;Structural Elucidation Based on Photo-CIDNP NMR;Unsupervised Refinement of Protein Structures;RNA Heterogeneity Visualized Under AFM